Selvaratnam R - Search Results

1

Mapping allostery through the covariance analysis of NMR chemical shifts.

Selvaratnam R, Chowdhury S, VanSchouwen B, Melacini G. Selvaratnam R, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6133-8. doi: 10.1073/pnas.1017311108. Epub 2011 Mar 28. Proc Natl Acad Sci U S A. 2011. PMID: 21444788 Free PMC article.

2

Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP.

Das R, Mazhab-Jafari MT, Chowdhury S, SilDas S, Selvaratnam R, Melacini G. Das R, et al. Among authors: selvaratnam r. J Biol Chem. 2008 Jul 11;283(28):19691-703. doi: 10.1074/jbc.M802164200. Epub 2008 Apr 14. J Biol Chem. 2008. PMID: 18411261 Free article.

3

Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

Das R, Chowdhury S, Mazhab-Jafari MT, Sildas S, Selvaratnam R, Melacini G. Das R, et al. Among authors: selvaratnam r. J Biol Chem. 2009 Aug 28;284(35):23682-96. doi: 10.1074/jbc.M109.011700. Epub 2009 Apr 29. J Biol Chem. 2009. PMID: 19403523 Free PMC article.

4

Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC).

VanSchouwen B, Selvaratnam R, Fogolari F, Melacini G. VanSchouwen B, et al. Among authors: selvaratnam r. J Biol Chem. 2011 Dec 9;286(49):42655-42669. doi: 10.1074/jbc.M111.277723. Epub 2011 Aug 26. J Biol Chem. 2011. PMID: 21873431 Free PMC article.

5

cAMP-dependent allostery and dynamics in Epac: an NMR view.

Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G. Selvaratnam R, et al. Biochem Soc Trans. 2012 Feb;40(1):219-23. doi: 10.1042/BST20110628. Biochem Soc Trans. 2012. PMID: 22260694 Review.

6

The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.

Selvaratnam R, VanSchouwen B, Fogolari F, Mazhab-Jafari MT, Das R, Melacini G. Selvaratnam R, et al. Biophys J. 2012 Feb 8;102(3):630-9. doi: 10.1016/j.bpj.2011.12.030. Epub 2012 Feb 7. Biophys J. 2012. PMID: 22325287 Free PMC article.

7

The auto-inhibitory role of the EPAC hinge helix as mapped by NMR.

Selvaratnam R, Mazhab-Jafari MT, Das R, Melacini G. Selvaratnam R, et al. PLoS One. 2012;7(11):e48707. doi: 10.1371/journal.pone.0048707. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185272 Free PMC article.

8

Signaling through dynamic linkers as revealed by PKA.

Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. Akimoto M, et al. Among authors: selvaratnam r. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14231-6. doi: 10.1073/pnas.1312644110. Epub 2013 Aug 14. Proc Natl Acad Sci U S A. 2013. PMID: 23946424 Free PMC article.

9

Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.

Boulton S, Akimoto M, VanSchouwen B, Moleschi K, Selvaratnam R, Giri R, Melacini G. Boulton S, et al. Among authors: selvaratnam r. Biochem Soc Trans. 2014 Apr;42(2):302-7. doi: 10.1042/BST20130282. Biochem Soc Trans. 2014. PMID: 24646235 Review.

10

A tool set to map allosteric networks through the NMR chemical shift covariance analysis.

Boulton S, Akimoto M, Selvaratnam R, Bashiri A, Melacini G. Boulton S, et al. Among authors: selvaratnam r. Sci Rep. 2014 Dec 8;4:7306. doi: 10.1038/srep07306. Sci Rep. 2014. PMID: 25482377 Free PMC article.

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