Saavedra JE - Search Results

1

Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas.

Kogias E, Osterberg N, Baumer B, Psarras N, Koentges C, Papazoglou A, Saavedra JE, Keefer LK, Weyerbrock A. Kogias E, et al. Among authors: saavedra je. Int J Cancer. 2012 Mar 1;130(5):1184-94. doi: 10.1002/ijc.26106. Epub 2011 Jul 21. Int J Cancer. 2012. PMID: 21455987 Free PMC article.

2

Differential effects of nitric oxide on blood-brain barrier integrity and cerebral blood flow in intracerebral C6 gliomas.

Weyerbrock A, Walbridge S, Saavedra JE, Keefer LK, Oldfield EH. Weyerbrock A, et al. Among authors: saavedra je. Neuro Oncol. 2011 Feb;13(2):203-11. doi: 10.1093/neuonc/noq161. Epub 2010 Nov 1. Neuro Oncol. 2011. PMID: 21041233 Free PMC article.

3

JS-K, a glutathione S-transferase-activated nitric oxide donor with antineoplastic activity in malignant gliomas.

Weyerbrock A, Osterberg N, Psarras N, Baumer B, Kogias E, Werres A, Bette S, Saavedra JE, Keefer LK, Papazoglou A. Weyerbrock A, et al. Among authors: saavedra je. Neurosurgery. 2012 Feb;70(2):497-510; discussion 510. doi: 10.1227/NEU.0b013e31823209cf. Neurosurgery. 2012. PMID: 21849924 Free PMC article.

4

Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI.

Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A. Weidensteiner C, et al. Among authors: saavedra je. Nitric Oxide. 2013 Apr 1;30:17-25. doi: 10.1016/j.niox.2013.01.003. Epub 2013 Jan 28. Nitric Oxide. 2013. PMID: 23370169 Free PMC article.

5

The nitric oxide donor JS-K sensitizes U87 glioma cells to repetitive irradiation.

Heckler M, Osterberg N, Guenzle J, Thiede-Stan NK, Reichardt W, Weidensteiner C, Saavedra JE, Weyerbrock A. Heckler M, et al. Among authors: saavedra je. Tumour Biol. 2017 Jun;39(6):1010428317703922. doi: 10.1177/1010428317703922. Tumour Biol. 2017. PMID: 28653883 Free article.

6

Selective opening of the blood-tumor barrier by a nitric oxide donor and long-term survival in rats with C6 gliomas.

Weyerbrock A, Walbridge S, Pluta RM, Saavedra JE, Keefer LK, Oldfield EH. Weyerbrock A, et al. Among authors: saavedra je. J Neurosurg. 2003 Oct;99(4):728-37. doi: 10.3171/jns.2003.99.4.0728. J Neurosurg. 2003. PMID: 14567609

7

Nitric oxide released from JS-K induces cell death by mitotic catastrophe as part of necrosis in glioblastoma multiforme.

Günzle J, Osterberg N, Saavedra JE, Weyerbrock A. Günzle J, et al. Among authors: saavedra je. Cell Death Dis. 2016 Sep 1;7(9):e2349. doi: 10.1038/cddis.2016.254. Cell Death Dis. 2016. PMID: 27584787 Free PMC article.

8

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.

Shami PJ, Saavedra JE, Wang LY, Bonifant CL, Diwan BA, Singh SV, Gu Y, Fox SD, Buzard GS, Citro ML, Waterhouse DJ, Davies KM, Ji X, Keefer LK. Shami PJ, et al. Among authors: saavedra je. Mol Cancer Ther. 2003 Apr;2(4):409-17. Mol Cancer Ther. 2003. PMID: 12700285

9

Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.

Findlay VJ, Townsend DM, Saavedra JE, Buzard GS, Citro ML, Keefer LK, Ji X, Tew KD. Findlay VJ, et al. Among authors: saavedra je. Mol Pharmacol. 2004 May;65(5):1070-9. doi: 10.1124/mol.65.5.1070. Mol Pharmacol. 2004. PMID: 15102935 Free PMC article.

10

A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins.

Townsend DM, Findlay VJ, Fazilev F, Ogle M, Fraser J, Saavedra JE, Ji X, Keefer LK, Tew KD. Townsend DM, et al. Among authors: saavedra je. Mol Pharmacol. 2006 Feb;69(2):501-8. doi: 10.1124/mol.105.018523. Epub 2005 Nov 15. Mol Pharmacol. 2006. PMID: 16288082 Free PMC article.

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