van Westen GJ - Search Results

1

Chemogenomics approaches for receptor deorphanization and extensions of the chemogenomics concept to phenotypic space.

van der Horst E, Peironcely JE, van Westen GJ, van den Hoven OO, Galloway WR, Spring DR, Wegner JK, van Vlijmen HW, Ijzerman AP, Overington JP, Bender A. van der Horst E, et al. Among authors: van westen gj, van vlijmen hw, van den hoven oo. Curr Top Med Chem. 2011;11(15):1964-77. doi: 10.2174/156802611796391230. Curr Top Med Chem. 2011. PMID: 21470175 Review.

2

Mining protein dynamics from sets of crystal structures using "consensus structures".

van Westen GJ, Wegner JK, Bender A, Ijzerman AP, van Vlijmen HW. van Westen GJ, et al. Among authors: van vlijmen hw. Protein Sci. 2010 Apr;19(4):742-52. doi: 10.1002/pro.350. Protein Sci. 2010. PMID: 20120021 Free PMC article.

3

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation.

Peeters MC, van Westen GJ, Li Q, IJzerman AP. Peeters MC, et al. Among authors: van westen gj. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. doi: 10.1016/j.tips.2010.10.001. Trends Pharmacol Sci. 2011. PMID: 21075459 Review.

4

Three "hotspots" important for adenosine A(2B) receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop.

Peeters MC, Li Q, van Westen GJ, Ijzerman AP. Peeters MC, et al. Among authors: van westen gj. Purinergic Signal. 2012 Mar;8(1):23-38. doi: 10.1007/s11302-011-9251-x. Epub 2011 Aug 5. Purinergic Signal. 2012. PMID: 21818573 Free PMC article.

5

Which compound to select in lead optimization? Prospectively validated proteochemometric models guide preclinical development.

van Westen GJ, Wegner JK, Geluykens P, Kwanten L, Vereycken I, Peeters A, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. Among authors: van vlijmen hw. PLoS One. 2011;6(11):e27518. doi: 10.1371/journal.pone.0027518. Epub 2011 Nov 23. PLoS One. 2011. PMID: 22132107 Free PMC article.

6

Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data.

van Westen GJ, van den Hoven OO, van der Pijl R, Mulder-Krieger T, de Vries H, Wegner JK, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. Among authors: van der pijl r, van vlijmen hw, van den hoven oo. J Med Chem. 2012 Aug 23;55(16):7010-20. doi: 10.1021/jm3003069. Epub 2012 Aug 3. J Med Chem. 2012. PMID: 22827545

7

A ligand's-eye view of protein similarity.

van Westen GJ, Overington JP. van Westen GJ, et al. Nat Methods. 2013 Feb;10(2):116-7. doi: 10.1038/nmeth.2339. Nat Methods. 2013. PMID: 23361090 No abstract available.

8

Significantly improved HIV inhibitor efficacy prediction employing proteochemometric models generated from antivirogram data.

van Westen GJ, Hendriks A, Wegner JK, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. Among authors: van vlijmen hw. PLoS Comput Biol. 2013;9(2):e1002899. doi: 10.1371/journal.pcbi.1002899. Epub 2013 Feb 21. PLoS Comput Biol. 2013. PMID: 23436985 Free PMC article.

9

Benchmarking of protein descriptor sets in proteochemometric modeling (part 1): comparative study of 13 amino acid descriptor sets.

van Westen GJ, Swier RF, Wegner JK, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. Among authors: van vlijmen hw. J Cheminform. 2013 Sep 23;5(1):41. doi: 10.1186/1758-2946-5-41. J Cheminform. 2013. PMID: 24059694 Free PMC article.

10

Benchmarking of protein descriptor sets in proteochemometric modeling (part 2): modeling performance of 13 amino acid descriptor sets.

van Westen GJ, Swier RF, Cortes-Ciriano I, Wegner JK, Overington JP, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. Among authors: van vlijmen hw. J Cheminform. 2013 Sep 24;5(1):42. doi: 10.1186/1758-2946-5-42. J Cheminform. 2013. PMID: 24059743 Free PMC article.

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