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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. Fernandez-Capetillo O, et al. Among authors: chen j, chen ht. Nat Cell Biol. 2002 Dec;4(12):993-7. doi: 10.1038/ncb884. Nat Cell Biol. 2002. PMID: 12447390
53BP1 is required for class switch recombination.
Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. Ward IM, et al. Among authors: chen j, chen l. J Cell Biol. 2004 May 24;165(4):459-64. doi: 10.1083/jcb.200403021. J Cell Biol. 2004. PMID: 15159415 Free PMC article.
MDC1 regulates DNA-PK autophosphorylation in response to DNA damage.
Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. Lou Z, et al. Among authors: chen j, chen bp, chen dj. J Biol Chem. 2004 Nov 5;279(45):46359-62. doi: 10.1074/jbc.C400375200. Epub 2004 Sep 17. J Biol Chem. 2004. PMID: 15377652 Free article.
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