Wang HG - Search Results

1

Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis.

Kulkarni SS, Hu X, Doi K, Wang HG, Manetsch R. Kulkarni SS, et al. Among authors: wang hg. ACS Chem Biol. 2011 Jul 15;6(7):724-32. doi: 10.1021/cb200085q. Epub 2011 May 5. ACS Chem Biol. 2011. PMID: 21506574 Free PMC article.

2

Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides.

Hu X, Sun J, Wang HG, Manetsch R. Hu X, et al. Among authors: wang hg. J Am Chem Soc. 2008 Oct 22;130(42):13820-1. doi: 10.1021/ja802683u. Epub 2008 Sep 24. J Am Chem Soc. 2008. PMID: 18811158 Free PMC article.

3

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM. Kazi A, et al. Among authors: wang hg. J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638. Epub 2010 Dec 9. J Biol Chem. 2011. PMID: 21148306 Free PMC article.

4

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction.

Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR. Kim YB, et al. Among authors: wang hg. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5961-5. doi: 10.1016/j.bmcl.2012.07.050. Epub 2012 Jul 24. Bioorg Med Chem Lett. 2012. PMID: 22901384 Free PMC article.

5

Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.

Muppidi A, Doi K, Edwardraja S, Drake EJ, Gulick AM, Wang HG, Lin Q. Muppidi A, et al. Among authors: wang hg. J Am Chem Soc. 2012 Sep 12;134(36):14734-7. doi: 10.1021/ja306864v. Epub 2012 Sep 4. J Am Chem Soc. 2012. PMID: 22920569 Free PMC article.

6

Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells.

Muppidi A, Doi K, Edwardraja S, Pulavarti SV, Szyperski T, Wang HG, Lin Q. Muppidi A, et al. Among authors: wang hg. Bioconjug Chem. 2014 Feb 19;25(2):424-32. doi: 10.1021/bc4005574. Epub 2014 Jan 22. Bioconjug Chem. 2014. PMID: 24410055 Free PMC article.

7

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation.

Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, Loughran TP Jr, Sebti S, Wang HG. Doi K, et al. Among authors: wang hg. J Biol Chem. 2012 Mar 23;287(13):10224-10235. doi: 10.1074/jbc.M111.334532. Epub 2012 Feb 6. J Biol Chem. 2012. PMID: 22311987 Free PMC article.

8

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells.

Pandey MK, Gowda K, Doi K, Sharma AK, Wang HG, Amin S. Pandey MK, et al. Among authors: wang hg. PLoS One. 2013 Nov 4;8(11):e78570. doi: 10.1371/journal.pone.0078570. eCollection 2013. PLoS One. 2013. PMID: 24223823 Free PMC article.

9

Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells.

Doi K, Gowda K, Liu Q, Lin JM, Sung SS, Dower C, Claxton D, Loughran TP Jr, Amin S, Wang HG. Doi K, et al. Among authors: wang hg. Cancer Biol Ther. 2014;15(12):1688-99. doi: 10.4161/15384047.2014.972799. Cancer Biol Ther. 2014. PMID: 25535900 Free PMC article.

10

Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers.

Muppidi A, Doi K, Ramil CP, Wang HG, Lin Q. Muppidi A, et al. Among authors: wang hg. Tetrahedron. 2014 Oct 21;70(42):7740-7745. doi: 10.1016/j.tet.2014.05.104. Tetrahedron. 2014. PMID: 25267861 Free PMC article.

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