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Page 1
Discovery, synthesis and biological evaluation of novel glucokinase activators.
McKerrecher D, Allen JV, Bowker SS, Boyd S, Caulkett PW, Currie GS, Davies CD, Fenwick ML, Gaskin H, Grange E, Hargreaves RB, Hayter BR, James R, Johnson KM, Johnstone C, Jones CD, Lackie S, Rayner JW, Walker RP. McKerrecher D, et al. Among authors: rayner jw. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2103-6. doi: 10.1016/j.bmcl.2005.01.087. Bioorg Med Chem Lett. 2005. PMID: 15808477
Design of a potent, soluble glucokinase activator with excellent in vivo efficacy.
McKerrecher D, Allen JV, Caulkett PW, Donald CS, Fenwick ML, Grange E, Johnson KM, Johnstone C, Jones CD, Pike KG, Rayner JW, Walker RP. McKerrecher D, et al. Among authors: rayner jw. Bioorg Med Chem Lett. 2006 May 15;16(10):2705-9. doi: 10.1016/j.bmcl.2006.02.022. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503142
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.
Block MH, Boyer S, Brailsford W, Brittain DR, Carroll D, Chapman S, Clarke DS, Donald CS, Foote KM, Godfrey L, Ladner A, Marsham PR, Masters DJ, Mee CD, O'Donovan MR, Pease JE, Pickup AG, Rayner JW, Roberts A, Schofield P, Suleman A, Turnbull AV. Block MH, et al. Among authors: rayner jw. J Med Chem. 2002 Aug 1;45(16):3509-23. doi: 10.1021/jm011125x. J Med Chem. 2002. PMID: 12139462