Lu Y - Search Results

1

Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents.

Lu Y, Li CM, Wang Z, Chen J, Mohler ML, Li W, Dalton JT, Miller DD. Lu Y, et al. J Med Chem. 2011 Jul 14;54(13):4678-93. doi: 10.1021/jm2003427. Epub 2011 Jun 7. J Med Chem. 2011. PMID: 21557538 Free PMC article.

2

Synthesis and antiproliferative activity of thiazolidine analogs for melanoma.

Li W, Lu Y, Wang Z, Dalton JT, Miller DD. Li W, et al. Among authors: lu y. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4113-7. doi: 10.1016/j.bmcl.2007.05.059. Epub 2007 May 23. Bioorg Med Chem Lett. 2007. PMID: 17561392

3

Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma.

Chen J, Wang Z, Lu Y, Dalton JT, Miller DD, Li W. Chen J, et al. Among authors: lu y. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3183-7. doi: 10.1016/j.bmcl.2008.04.073. Epub 2008 May 1. Bioorg Med Chem Lett. 2008. PMID: 18477505 Free PMC article.

4

Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships.

Lu Y, Li CM, Wang Z, Ross CR 2nd, Chen J, Dalton JT, Li W, Miller DD. Lu Y, et al. J Med Chem. 2009 Mar 26;52(6):1701-11. doi: 10.1021/jm801449a. J Med Chem. 2009. PMID: 19243174 Free PMC article.

5

Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents.

Lu Y, Wang Z, Li CM, Chen J, Dalton JT, Li W, Miller DD. Lu Y, et al. Bioorg Med Chem. 2010 Jan 15;18(2):477-95. doi: 10.1016/j.bmc.2009.12.020. Epub 2009 Dec 11. Bioorg Med Chem. 2010. PMID: 20056548 Free PMC article.

6

Synthesis, formulation and in vitro evaluation of a novel microtubule destabilizer, SMART-100.

Li F, Lu Y, Li W, Miller DD, Mahato RI. Li F, et al. Among authors: lu y. J Control Release. 2010 Apr 2;143(1):151-8. doi: 10.1016/j.jconrel.2009.12.028. Epub 2010 Jan 7. J Control Release. 2010. PMID: 20060430

7

Drug metabolism and pharmacokinetics of 4-substituted methoxybenzoyl-aryl-thiazoles.

Li CM, Lu Y, Narayanan R, Miller DD, Dalton JT. Li CM, et al. Among authors: lu y. Drug Metab Dispos. 2010 Nov;38(11):2032-9. doi: 10.1124/dmd.110.034348. Epub 2010 Jul 30. Drug Metab Dispos. 2010. PMID: 20675405

8

Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents.

Chen J, Wang Z, Li CM, Lu Y, Vaddady PK, Meibohm B, Dalton JT, Miller DD, Li W. Chen J, et al. Among authors: lu y. J Med Chem. 2010 Oct 28;53(20):7414-27. doi: 10.1021/jm100884b. J Med Chem. 2010. PMID: 20919720 Free PMC article.

9

Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability.

Li CM, Chen J, Lu Y, Narayanan R, Parke DN, Li W, Ahn S, Miller DD, Dalton JT. Li CM, et al. Among authors: lu y. Drug Metab Dispos. 2011 Oct;39(10):1833-9. doi: 10.1124/dmd.110.036616. Epub 2011 Jul 8. Drug Metab Dispos. 2011. PMID: 21742898 Free PMC article.

10

Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization.

Chen J, Li CM, Wang J, Ahn S, Wang Z, Lu Y, Dalton JT, Miller DD, Li W. Chen J, et al. Among authors: lu y. Bioorg Med Chem. 2011 Aug 15;19(16):4782-95. doi: 10.1016/j.bmc.2011.06.084. Epub 2011 Jul 1. Bioorg Med Chem. 2011. PMID: 21775150 Free PMC article.

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