Wang H - Search Results

1

γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.

Huang H, Wang H, Voehler MW, Kozekova A, Rizzo CJ, McCullough AK, Lloyd RS, Stone MP. Huang H, et al. Among authors: wang h. Chem Res Toxicol. 2011 Jul 18;24(7):1123-33. doi: 10.1021/tx200113n. Epub 2011 May 11. Chem Res Toxicol. 2011. PMID: 21561113 Free PMC article.

2

Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal.

Wang H, Kozekov ID, Harris TM, Rizzo CJ. Wang H, et al. J Am Chem Soc. 2003 May 14;125(19):5687-700. doi: 10.1021/ja0288800. J Am Chem Soc. 2003. PMID: 12733907

3

A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine.

Wang H, Marnett LJ, Harris TM, Rizzo CJ. Wang H, et al. Chem Res Toxicol. 2004 Feb;17(2):144-9. doi: 10.1021/tx034174g. Chem Res Toxicol. 2004. PMID: 14967001

4

Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5'-CpG-3' sequence by the acrolein-derived gamma-OH-1,N2-propano-2'-deoxyguanosine DNA adduct.

Cho YJ, Kim HY, Huang H, Slutsky A, Minko IG, Wang H, Nechev LV, Kozekov ID, Kozekova A, Tamura P, Jacob J, Voehler M, Harris TM, Lloyd RS, Rizzo CJ, Stone MP. Cho YJ, et al. Among authors: wang h. J Am Chem Soc. 2005 Dec 21;127(50):17686-96. doi: 10.1021/ja053897e. J Am Chem Soc. 2005. PMID: 16351098 Free PMC article.

5

Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence.

Cho YJ, Wang H, Kozekov ID, Kurtz AJ, Jacob J, Voehler M, Smith J, Harris TM, Lloyd RS, Rizzo CJ, Stone MP. Cho YJ, et al. Among authors: wang h. Chem Res Toxicol. 2006 Feb;19(2):195-208. doi: 10.1021/tx050239z. Chem Res Toxicol. 2006. PMID: 16485895 Free PMC article.

6

Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence.

Cho YJ, Wang H, Kozekov ID, Kozekova A, Kurtz AJ, Jacob J, Voehler M, Smith J, Harris TM, Rizzo CJ, Lloyd RS, Stone MP. Cho YJ, et al. Among authors: wang h. Chem Res Toxicol. 2006 Aug;19(8):1019-29. doi: 10.1021/tx0600604. Chem Res Toxicol. 2006. PMID: 16918240

M. (2003) J. Am. Chem. Soc. 125, 50-61; Cho, Y.-J., Wang, H., Kozekov, I. D., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. ...Res. Toxicol. 19, 195-208]. Analysis of (1)H NOE data, chemical shift perturbations, and deoxyribose pseudorotations a …

M. (2003) J. Am. Chem. Soc. 125, 50-61; Cho, Y.-J., Wang, H., Kozekov, I. D., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., …

7

Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy.

Wang H, Kozekov ID, Kozekova A, Tamura PJ, Marnett LJ, Harris TM, Rizzo CJ. Wang H, et al. Chem Res Toxicol. 2006 Nov;19(11):1467-74. doi: 10.1021/tx060137o. Chem Res Toxicol. 2006. PMID: 17112234 Free PMC article.

8

Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.

Stone MP, Cho YJ, Huang H, Kim HY, Kozekov ID, Kozekova A, Wang H, Minko IG, Lloyd RS, Harris TM, Rizzo CJ. Stone MP, et al. Among authors: wang h. Acc Chem Res. 2008 Jul;41(7):793-804. doi: 10.1021/ar700246x. Epub 2008 May 24. Acc Chem Res. 2008. PMID: 18500830 Free PMC article.

9

Rearrangement of the (6S,8R,11S) and (6R,8S,11R) exocyclic 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal to N2-deoxyguanosine cyclic hemiacetal adducts when placed complementary to cytosine in duplex DNA.

Huang H, Wang H, Qi N, Kozekova A, Rizzo CJ, Stone MP. Huang H, et al. Among authors: wang h. J Am Chem Soc. 2008 Aug 20;130(33):10898-906. doi: 10.1021/ja801824b. Epub 2008 Jul 29. J Am Chem Soc. 2008. PMID: 18661996 Free PMC article.

Moreover, as compared to the exocyclic 1,N(2)-dG adducts of acrolein and crotonaldehyde, the cross-linking reaction is slow (Wang, H.; Kozekov, I. D.; Harris, T. M.; Rizzo, C. J. J. Am. Chem. Soc. 2003, 125, 5687-5700). ...

Moreover, as compared to the exocyclic 1,N(2)-dG adducts of acrolein and crotonaldehyde, the cross-linking reaction is slow (Wang, …

10

The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence.

Huang H, Wang H, Qi N, Lloyd RS, Rizzo CJ, Stone MP. Huang H, et al. Among authors: wang h. Biochemistry. 2008 Nov 4;47(44):11457-72. doi: 10.1021/bi8011143. Epub 2008 Oct 11. Biochemistry. 2008. PMID: 18847226 Free PMC article.

Both exist primarily as diastereomeric cyclic hemiacetals when placed into duplex DNA [Huang, H., Wang, H., Qi, N., Kozekova, A., Rizzo, C. J., and Stone, M. P. (2008) J. Am. Chem. ...

Both exist primarily as diastereomeric cyclic hemiacetals when placed into duplex DNA [Huang, H., Wang, H., Qi, N., Koz …

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