Sexton PM - Search Results

1

Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.

Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ. Dong M, et al. Among authors: sexton pm. J Biol Chem. 2011 Jul 8;286(27):23888-99. doi: 10.1074/jbc.M111.245969. Epub 2011 May 12. J Biol Chem. 2011. PMID: 21566140 Free PMC article.

2

Novel receptor partners and function of receptor activity-modifying proteins.

Christopoulos A, Christopoulos G, Morfis M, Udawela M, Laburthe M, Couvineau A, Kuwasako K, Tilakaratne N, Sexton PM. Christopoulos A, et al. Among authors: sexton pm. J Biol Chem. 2003 Jan 31;278(5):3293-7. doi: 10.1074/jbc.C200629200. Epub 2002 Nov 21. J Biol Chem. 2003. PMID: 12446722 Free article.

3

Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor.

Pham V, Wade JD, Purdue BW, Sexton PM. Pham V, et al. Among authors: sexton pm. J Biol Chem. 2004 Feb 20;279(8):6720-9. doi: 10.1074/jbc.M307214200. Epub 2003 Nov 17. J Biol Chem. 2004. PMID: 14623894 Free article.

4

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling.

Pham V, Dong M, Wade JD, Miller LJ, Morton CJ, Ng HL, Parker MW, Sexton PM. Pham V, et al. Among authors: sexton pm. J Biol Chem. 2005 Aug 5;280(31):28610-22. doi: 10.1074/jbc.M503272200. Epub 2005 Jun 1. J Biol Chem. 2005. PMID: 15929987 Free article.

5

Constitutive formation of oligomeric complexes between family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors.

Harikumar KG, Morfis MM, Lisenbee CS, Sexton PM, Miller LJ. Harikumar KG, et al. Among authors: sexton pm. Mol Pharmacol. 2006 Jan;69(1):363-73. doi: 10.1124/mol.105.015776. Epub 2005 Oct 21. Mol Pharmacol. 2006. PMID: 16244179

6

Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ. Dong M, et al. Among authors: sexton pm. Mol Pharmacol. 2007 Aug;72(2):280-90. doi: 10.1124/mol.107.035402. Epub 2007 May 2. Mol Pharmacol. 2007. PMID: 17475809

7

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.

Avlani VA, Gregory KJ, Morton CJ, Parker MW, Sexton PM, Christopoulos A. Avlani VA, et al. Among authors: sexton pm. J Biol Chem. 2007 Aug 31;282(35):25677-86. doi: 10.1074/jbc.M702311200. Epub 2007 Jun 25. J Biol Chem. 2007. PMID: 17591774 Free article.

8

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs.

Bisson WH, Cheltsov AV, Bruey-Sedano N, Lin B, Chen J, Goldberger N, May LT, Christopoulos A, Dalton JT, Sexton PM, Zhang XK, Abagyan R. Bisson WH, et al. Among authors: sexton pm. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11927-32. doi: 10.1073/pnas.0609752104. Epub 2007 Jul 2. Proc Natl Acad Sci U S A. 2007. PMID: 17606915 Free PMC article.

9

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.

Harikumar KG, Lam PC, Dong M, Sexton PM, Abagyan R, Miller LJ. Harikumar KG, et al. Among authors: sexton pm. J Biol Chem. 2007 Nov 9;282(45):32834-43. doi: 10.1074/jbc.M704563200. Epub 2007 Sep 7. J Biol Chem. 2007. PMID: 17827151 Free article.

10

Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor.

Harikumar KG, Morfis MM, Sexton PM, Miller LJ. Harikumar KG, et al. Among authors: sexton pm. J Mol Neurosci. 2008 Nov;36(1-3):279-85. doi: 10.1007/s12031-008-9060-z. Epub 2008 Apr 10. J Mol Neurosci. 2008. PMID: 18401761 Free PMC article.

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