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Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.
Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Huang HS, et al. Among authors: zylka mj. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726. Nature. 2011. PMID: 22190039 Free PMC article.
Topoisomerases facilitate transcription of long genes linked to autism.
King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ. King IF, et al. Among authors: zylka mj. Nature. 2013 Sep 5;501(7465):58-62. doi: 10.1038/nature12504. Epub 2013 Aug 28. Nature. 2013. PMID: 23995680 Free PMC article.
Topoisomerase 1 inhibition reversibly impairs synaptic function.
Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ. Mabb AM, et al. Among authors: zylka mj. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17290-5. doi: 10.1073/pnas.1413204111. Epub 2014 Nov 17. Proc Natl Acad Sci U S A. 2014. PMID: 25404338 Free PMC article.
Gene length matters in neurons.
Zylka MJ, Simon JM, Philpot BD. Zylka MJ, et al. Neuron. 2015 Apr 22;86(2):353-5. doi: 10.1016/j.neuron.2015.03.059. Neuron. 2015. PMID: 25905808 Free PMC article.
An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A.
Yi JJ, Berrios J, Newbern JM, Snider WD, Philpot BD, Hahn KM, Zylka MJ. Yi JJ, et al. Among authors: zylka mj. Cell. 2015 Aug 13;162(4):795-807. doi: 10.1016/j.cell.2015.06.045. Epub 2015 Aug 6. Cell. 2015. PMID: 26255772 Free PMC article.
112 results