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Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL.
Hanash AM, Kappel LW, Yim NL, Nejat RA, Goldberg GL, Smith OM, Rao UK, Dykstra L, Na IK, Holland AM, Dudakov JA, Liu C, Murphy GF, Leonard WJ, Heller G, van den Brink MR. Hanash AM, et al. Among authors: leonard wj. Blood. 2011 Jul 14;118(2):446-55. doi: 10.1182/blood-2010-07-294785. Epub 2011 May 19. Blood. 2011. PMID: 21596854 Free PMC article.
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Mazzucchelli R, Hixon JA, Spolski R, Chen X, Li WQ, Hall VL, Willette-Brown J, Hurwitz AA, Leonard WJ, Durum SK. Mazzucchelli R, et al. Among authors: leonard wj. Blood. 2008 Oct 15;112(8):3283-92. doi: 10.1182/blood-2008-02-137414. Epub 2008 Jul 29. Blood. 2008. PMID: 18664628 Free PMC article.
The molecular basis of IL-21-mediated proliferation.
Zeng R, Spolski R, Casas E, Zhu W, Levy DE, Leonard WJ. Zeng R, et al. Among authors: leonard wj. Blood. 2007 May 15;109(10):4135-42. doi: 10.1182/blood-2006-10-054973. Epub 2007 Jan 18. Blood. 2007. PMID: 17234735 Free PMC article.
Critical role for Rsk2 in T-lymphocyte activation.
Lin JX, Spolski R, Leonard WJ. Lin JX, et al. Among authors: leonard wj. Blood. 2008 Jan 15;111(2):525-33. doi: 10.1182/blood-2007-02-072207. Epub 2007 Oct 15. Blood. 2008. PMID: 17938253 Free PMC article.
366 results