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(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.
Valentine WJ, Kiss GN, Liu J, E S, Gotoh M, Murakami-Murofushi K, Pham TC, Baker DL, Parrill AL, Lu X, Sun C, Bittman R, Pyne NJ, Tigyi G. Valentine WJ, et al. Among authors: bittman r. Cell Signal. 2010 Oct;22(10):1543-53. doi: 10.1016/j.cellsig.2010.05.023. Epub 2010 Jun 4. Cell Signal. 2010. PMID: 20566326 Free PMC article.
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ. Tonelli F, et al. Among authors: bittman r. Cell Signal. 2010 Oct;22(10):1536-42. doi: 10.1016/j.cellsig.2010.05.022. Epub 2010 Jun 4. Cell Signal. 2010. PMID: 20570726 Free PMC article.
The role of sphingosine 1-phosphate in inflammation and cancer.
Pyne NJ, Ohotski J, Bittman R, Pyne S. Pyne NJ, et al. Among authors: bittman r. Adv Biol Regul. 2014 Jan;54:121-9. doi: 10.1016/j.jbior.2013.08.005. Epub 2013 Sep 11. Adv Biol Regul. 2014. PMID: 24070975 Free article. Review.
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.
Ohotski J, Rosen H, Bittman R, Pyne S, Pyne NJ. Ohotski J, et al. Among authors: bittman r. Cell Signal. 2014 May;26(5):1040-7. doi: 10.1016/j.cellsig.2014.01.023. Epub 2014 Jan 29. Cell Signal. 2014. PMID: 24486401 Free article.
328 results