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Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.
Long JS, Edwards J, Watson C, Tovey S, Mair KM, Schiff R, Natarajan V, Pyne NJ, Pyne S. Long JS, et al. Among authors: pyne s, pyne nj. Mol Cell Biol. 2010 Aug;30(15):3827-41. doi: 10.1128/MCB.01133-09. Epub 2010 Jun 1. Mol Cell Biol. 2010. PMID: 20516217 Free PMC article.
Sphingosine 1-phosphate and cancer.
Pyne NJ, Pyne S. Pyne NJ, et al. Among authors: pyne s. Nat Rev Cancer. 2010 Jul;10(7):489-503. doi: 10.1038/nrc2875. Epub 2010 Jun 17. Nat Rev Cancer. 2010. PMID: 20555359 Review.
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ. Tonelli F, et al. Among authors: pyne s, pyne nj. Cell Signal. 2010 Oct;22(10):1536-42. doi: 10.1016/j.cellsig.2010.05.022. Epub 2010 Jun 4. Cell Signal. 2010. PMID: 20570726 Free PMC article.
428 results