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Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor.
Kedjouar B, Daunes S, Vilner BJ, Bowen WD, Klaebe A, Faye JC, Poirot M. Kedjouar B, et al. Among authors: poirot m. Biochem Pharmacol. 1999 Dec 15;58(12):1927-39. doi: 10.1016/s0006-2952(99)00285-3. Biochem Pharmacol. 1999. PMID: 10591147
Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.
Galés C, Poirot M, Taillefer J, Maigret B, Martinez J, Moroder L, Escrieut C, Pradayrol L, Fourmy D, Silvente-Poirot S. Galés C, et al. Among authors: poirot m. Mol Pharmacol. 2003 May;63(5):973-82. doi: 10.1124/mol.63.5.973. Mol Pharmacol. 2003. PMID: 12695525
Molecular characterization of the microsomal tamoxifen binding site.
Kedjouar B, de Médina P, Oulad-Abdelghani M, Payré B, Silvente-Poirot S, Favre G, Faye JC, Poirot M. Kedjouar B, et al. Among authors: poirot m. J Biol Chem. 2004 Aug 6;279(32):34048-61. doi: 10.1074/jbc.M405230200. Epub 2004 Jun 2. J Biol Chem. 2004. PMID: 15175332 Free article.
119 results