Clarke AR - Search Results

1

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites.

Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. Freir DB, et al. Among authors: clarke ar. Nat Commun. 2011 Jun 7;2:336. doi: 10.1038/ncomms1341. Nat Commun. 2011. PMID: 21654636 Free PMC article.

2

Pharmacological chaperone for the structured domain of human prion protein.

Nicoll AJ, Trevitt CR, Tattum MH, Risse E, Quarterman E, Ibarra AA, Wright C, Jackson GS, Sessions RB, Farrow M, Waltho JP, Clarke AR, Collinge J. Nicoll AJ, et al. Among authors: clarke ar. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17610-5. doi: 10.1073/pnas.1009062107. Epub 2010 Sep 27. Proc Natl Acad Sci U S A. 2010. PMID: 20876144 Free PMC article.

3

N-terminal domain of prion protein directs its oligomeric association.

Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR. Trevitt CR, et al. Among authors: clarke ar. J Biol Chem. 2014 Sep 12;289(37):25497-508. doi: 10.1074/jbc.M114.566588. Epub 2014 Jul 29. J Biol Chem. 2014. PMID: 25074940 Free PMC article.

4

A general model of prion strains and their pathogenicity.

Collinge J, Clarke AR. Collinge J, et al. Among authors: clarke ar. Science. 2007 Nov 9;318(5852):930-6. doi: 10.1126/science.1138718. Science. 2007. PMID: 17991853 Review.

5

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases.

Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J. Sandberg MK, et al. Among authors: clarke ar. Nature. 2011 Feb 24;470(7335):540-2. doi: 10.1038/nature09768. Nature. 2011. PMID: 21350487

6

Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked.

Sandberg MK, Al-Doujaily H, Sharps B, De Oliveira MW, Schmidt C, Richard-Londt A, Lyall S, Linehan JM, Brandner S, Wadsworth JD, Clarke AR, Collinge J. Sandberg MK, et al. Among authors: clarke ar. Nat Commun. 2014 Jul 9;5:4347. doi: 10.1038/ncomms5347. Nat Commun. 2014. PMID: 25005024 Free PMC article.

7

Rapid cell-surface prion protein conversion revealed using a novel cell system.

Goold R, Rabbanian S, Sutton L, Andre R, Arora P, Moonga J, Clarke AR, Schiavo G, Jat P, Collinge J, Tabrizi SJ. Goold R, et al. Among authors: clarke ar. Nat Commun. 2011;2:281. doi: 10.1038/ncomms1282. Nat Commun. 2011. PMID: 21505437 Free PMC article.

8

Elongated oligomers assemble into mammalian PrP amyloid fibrils.

Tattum MH, Cohen-Krausz S, Thumanu K, Wharton CW, Khalili-Shirazi A, Jackson GS, Orlova EV, Collinge J, Clarke AR, Saibil HR. Tattum MH, et al. Among authors: clarke ar. J Mol Biol. 2006 Mar 31;357(3):975-85. doi: 10.1016/j.jmb.2006.01.052. Epub 2006 Jan 31. J Mol Biol. 2006. PMID: 16473369

9

Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation.

Lewis PA, Tattum MH, Jones S, Bhelt D, Batchelor M, Clarke AR, Collinge J, Jackson GS. Lewis PA, et al. Among authors: clarke ar. J Gen Virol. 2006 Aug;87(Pt 8):2443-2449. doi: 10.1099/vir.0.81630-0. J Gen Virol. 2006. PMID: 16847141

10

Prion protein is necessary for normal synaptic function.

Collinge J, Whittington MA, Sidle KC, Smith CJ, Palmer MS, Clarke AR, Jefferys JG. Collinge J, et al. Among authors: clarke ar. Nature. 1994 Jul 28;370(6487):295-7. doi: 10.1038/370295a0. Nature. 1994. PMID: 8035877

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