Li W - Search Results

1

Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.

Cui W, Cui GZ, Li W, Zhang Z, Hu S, Mak S, Zhang H, Carlier PR, Choi CL, Wong YT, Lee SM, Han Y. Cui W, et al. Among authors: li w. Brain Res. 2011 Jul 15;1401:10-7. doi: 10.1016/j.brainres.2011.05.042. Epub 2011 May 25. Brain Res. 2011. PMID: 21665194

2

Preventing H₂O₂-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone.

Cui W, Li W, Zhao Y, Mak S, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han Y. Cui W, et al. Among authors: li w. Brain Res. 2011 Jun 7;1394:14-23. doi: 10.1016/j.brainres.2011.02.006. Epub 2011 Feb 9. Brain Res. 2011. PMID: 21315693

3

Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway.

Zhang H, Mak S, Cui W, Li W, Han R, Hu S, Ye M, Pi R, Han Y. Zhang H, et al. Among authors: li w. Neurochem Int. 2011 Dec;59(7):981-8. doi: 10.1016/j.neuint.2011.09.001. Epub 2011 Sep 10. Neurochem Int. 2011. PMID: 21939707

4

Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets.

Zhao Y, Dou J, Luo J, Li W, Chan HH, Cui W, Zhang H, Han R, Carlier PR, Zhang X, Han Y. Zhao Y, et al. Among authors: li w. Brain Res. 2011 Nov 3;1421:100-9. doi: 10.1016/j.brainres.2011.09.014. Epub 2011 Sep 16. Brain Res. 2011. PMID: 21978549

5

Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.

Cui W, Hu S, Chan HH, Luo J, Li W, Mak S, Choi TC, Rong J, Carlier PR, Han Y. Cui W, et al. Among authors: li w. Chem Biol Interact. 2013 Mar 25;203(1):365-70. doi: 10.1016/j.cbi.2012.10.003. Epub 2012 Oct 16. Chem Biol Interact. 2013. PMID: 23085120

6

East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.

Li WM, Kan KK, Carlier PR, Pang YP, Han YF. Li WM, et al. Curr Alzheimer Res. 2007 Sep;4(4):386-96. doi: 10.2174/156720507781788918. Curr Alzheimer Res. 2007. PMID: 17908041 Review.

7

Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.

Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, Tsim KW, Li M, Han Y. Li W, et al. Among authors: li c, li z, li m. J Biol Chem. 2005 May 6;280(18):18179-88. doi: 10.1074/jbc.M411085200. Epub 2005 Feb 14. J Biol Chem. 2005. PMID: 15710623 Free article.

8

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.

Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y. Fu H, et al. Among authors: li w. Eur J Pharmacol. 2009 Nov 25;623(1-3):14-21. doi: 10.1016/j.ejphar.2009.09.013. Epub 2009 Sep 16. Eur J Pharmacol. 2009. PMID: 19765582

9

PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis.

Cui W, Li W, Han R, Mak S, Zhang H, Hu S, Rong J, Han Y. Cui W, et al. Among authors: li w. Neurochem Int. 2011 Nov;59(6):945-53. doi: 10.1016/j.neuint.2011.07.005. Epub 2011 Jul 12. Neurochem Int. 2011. PMID: 21781996

10

Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase.

Cui W, Zhang Z, Li W, Mak S, Hu S, Zhang H, Yuan S, Rong J, Choi TC, Lee SM, Han Y. Cui W, et al. Among authors: li w. PLoS One. 2012;7(9):e46253. doi: 10.1371/journal.pone.0046253. Epub 2012 Sep 25. PLoS One. 2012. PMID: 23049997 Free PMC article.

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