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273 results

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Page 1
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F. Ceccarelli DF, et al. Among authors: webb dr. Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16. Cell. 2011. PMID: 21683433 Free article.
Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy.
Chen Q, Xie W, Kuhn DJ, Voorhees PM, Lopez-Girona A, Mendy D, Corral LG, Krenitsky VP, Xu W, Moutouh-de Parseval L, Webb DR, Mercurio F, Nakayama KI, Nakayama K, Orlowski RZ. Chen Q, et al. Among authors: webb dr. Blood. 2008 May 1;111(9):4690-9. doi: 10.1182/blood-2007-09-112904. Epub 2008 Feb 27. Blood. 2008. PMID: 18305219 Free PMC article.
Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases.
Xu Y, Li J, Ferguson GD, Mercurio F, Khambatta G, Morrison L, Lopez-Girona A, Corral LG, Webb DR, Bennett BL, Xie W. Xu Y, et al. Among authors: webb dr. Blood. 2009 Jul 9;114(2):338-45. doi: 10.1182/blood-2009-02-200543. Epub 2009 May 5. Blood. 2009. PMID: 19417207 Free article.
Influence of Th1 versus Th2 immune bias on viral, pathological, and immunological dynamics in SARS-CoV-2 variant-infected human ACE2 knock-in mice.
Verma SK, Ana-Sosa-Batiz F, Timis J, Shafee N, Maule E, Pinto PBA, Conner C, Valentine KM, Cowley DO, Miller R, Elong Ngono A, Tran L, Varghese K, Dos Santos Alves RP, Hastie KM, Saphire EO, Webb DR, Jarnagin K, Kim K, Shresta S. Verma SK, et al. Among authors: webb dr. EBioMedicine. 2024 Oct;108:105361. doi: 10.1016/j.ebiom.2024.105361. Epub 2024 Sep 30. EBioMedicine. 2024. PMID: 39353281 Free PMC article.
Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction-associated steatotic liver disease but is not altered by 6 weeks of exercise training.
Willis SA, Malaikah S, Bawden SJ, Sherry AP, Sargeant JA, Coull NA, Bradley CR, Rowlands A, Naim I, Ennequin G, Yates T, Waheed G, Gowland P, Stensel DJ, Webb DR, Davies MJ, Aithal GP, King JA. Willis SA, et al. Among authors: webb dr. Diabetes Obes Metab. 2024 Sep;26(9):4030-4042. doi: 10.1111/dom.15755. Epub 2024 Jul 8. Diabetes Obes Metab. 2024. PMID: 38978184 Clinical Trial.
Effectiveness of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in weight management services (STRIVE study): a multicentre, open-label, parallel-group, randomized controlled trial.
Papamargaritis D, Al-Najim W, Lim JZM, Crane J, Bodicoat DH, Barber S, Lean M, McGowan B, O'Shea D, Webb DR, Wilding JPH, le Roux CW, Davies MJ. Papamargaritis D, et al. Among authors: webb dr. Lancet Reg Health Eur. 2024 Feb 9;39:100853. doi: 10.1016/j.lanepe.2024.100853. eCollection 2024 Apr. Lancet Reg Health Eur. 2024. PMID: 38803628 Free PMC article.
273 results