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Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab.
Grisic AM, Xiong W, Tanneau L, Jönsson S, Friberg LE, Karlsson MO, Dai H, Zheng J, Girard P, Khandelwal A. Grisic AM, et al. Among authors: khandelwal a. Clin Cancer Res. 2022 Apr 1;28(7):1363-1371. doi: 10.1158/1078-0432.CCR-21-2662. Clin Cancer Res. 2022. PMID: 34921021 Free PMC article.
A multistate modeling and simulation framework to learn dose-response of oncology drugs: Application to bintrafusp alfa in non-small cell lung cancer.
Liu H, Milenković-Grišić AM, Krishnan SM, Jönsson S, Friberg LE, Girard P, Venkatakrishnan K, Vugmeyster Y, Khandelwal A, Karlsson MO. Liu H, et al. Among authors: khandelwal a. CPT Pharmacometrics Syst Pharmacol. 2023 Nov;12(11):1738-1750. doi: 10.1002/psp4.12976. Epub 2023 May 11. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37165943 Free PMC article.
Time-Varying Clearance and Impact of Disease State on the Pharmacokinetics of Avelumab in Merkel Cell Carcinoma and Urothelial Carcinoma.
Wilkins JJ, Brockhaus B, Dai H, Vugmeyster Y, White JT, Brar S, Bello CL, Neuteboom B, Wade JR, Girard P, Khandelwal A. Wilkins JJ, et al. Among authors: khandelwal a. CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):415-427. doi: 10.1002/psp4.12406. Epub 2019 Apr 25. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30980481 Free PMC article.
Population pharmacokinetic model selection assisted by machine learning.
Sibieude E, Khandelwal A, Girard P, Hesthaven JS, Terranova N. Sibieude E, et al. Among authors: khandelwal a. J Pharmacokinet Pharmacodyn. 2022 Apr;49(2):257-270. doi: 10.1007/s10928-021-09793-6. Epub 2021 Oct 27. J Pharmacokinet Pharmacodyn. 2022. PMID: 34708337 Free PMC article.
Pharmacometric modeling and machine learning analyses of prognostic and predictive factors in the JAVELIN Gastric 100 phase III trial of avelumab.
Terranova N, French J, Dai H, Wiens M, Khandelwal A, Ruiz-Garcia A, Manitz J, von Heydebreck A, Ruisi M, Chin K, Girard P, Venkatakrishnan K. Terranova N, et al. Among authors: khandelwal a. CPT Pharmacometrics Syst Pharmacol. 2022 Mar;11(3):333-347. doi: 10.1002/psp4.12754. Epub 2022 Jan 19. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 34971492 Free PMC article. Clinical Trial.
508 results