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Page 1
Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts.
Aschner Y, Nelson M, Brenner M, Roybal H, Beke K, Meador C, Foster D, Correll KA, Reynolds PR, Anderson K, Redente EF, Matsuda J, Riches DWH, Groshong SD, Pozzi A, Sap J, Wang Q, Rajshankar D, McCulloch CAG, Zemans RL, Downey GP. Aschner Y, et al. Among authors: downey gp. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L294-L311. doi: 10.1152/ajplung.00235.2019. Epub 2020 Jun 3. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32491951 Free PMC article.
Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.
Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Aschner Y, et al. Among authors: downey gp. Am J Pathol. 2014 May;184(5):1489-502. doi: 10.1016/j.ajpath.2014.01.016. Epub 2014 Mar 17. Am J Pathol. 2014. PMID: 24650563 Free PMC article.
Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences.
Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Vandivier RW, et al. Among authors: downey gp. Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L677-86. doi: 10.1152/ajplung.00030.2009. Epub 2009 Jul 24. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19633071 Free PMC article.
Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling.
Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Zemans RL, et al. Among authors: downey gp. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15990-5. doi: 10.1073/pnas.1110144108. Epub 2011 Aug 31. Proc Natl Acad Sci U S A. 2011. PMID: 21880956 Free PMC article.
Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.
Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Yamashita CM, et al. Among authors: downey gp. Am J Pathol. 2011 Oct;179(4):1733-45. doi: 10.1016/j.ajpath.2011.06.041. Epub 2011 Aug 24. Am J Pathol. 2011. PMID: 21871427 Free PMC article.
It's much more than just pretty pictures.
Henson PM, Downey GP, Irvin CG. Henson PM, et al. Among authors: downey gp. Am J Respir Cell Mol Biol. 2010 May;42(5):515-6. doi: 10.1165/rcmb.2010-0085ED. Am J Respir Cell Mol Biol. 2010. PMID: 20393072 No abstract available.
PTPα promotes fibroproliferative responses after acute lung injury.
Aschner Y, Correll KA, Beke KM, Foster DG, Roybal HM, Nelson MR, Meador CL, Strand M, Anderson KC, Moore CM, Reynolds PR, Kopf KW, Burnham EL, Downey GP. Aschner Y, et al. Among authors: downey gp. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L69-L83. doi: 10.1152/ajplung.00436.2021. Epub 2022 Jun 7. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35670474 Free PMC article.
241 results