Kuno M - Search Results

1

Pharmacological profile of FK881(ASP6537), a novel potent and selective cyclooxygenase-1 inhibitor.

Imanishi J, Morita Y, Yoshimi E, Kuroda K, Masunaga T, Yamagami K, Kuno M, Hamachi E, Aoki S, Takahashi F, Nakamura K, Miyata S, Ohkubo Y, Mutoh S. Imanishi J, et al. Among authors: kuno m. Biochem Pharmacol. 2011 Oct 1;82(7):746-54. doi: 10.1016/j.bcp.2011.06.035. Epub 2011 Jul 2. Biochem Pharmacol. 2011. PMID: 21745460

2

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model.

Ito M, Yamazaki S, Yamagami K, Kuno M, Morita Y, Okuma K, Nakamura K, Chida N, Inami M, Inoue T, Shirakami S, Higashi Y. Ito M, et al. Among authors: kuno m. J Pharmacol Sci. 2017 Jan;133(1):25-33. doi: 10.1016/j.jphs.2016.12.001. Epub 2016 Dec 23. J Pharmacol Sci. 2017. PMID: 28117214 Free article.

3

Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938.

Kuno M, Seki N, Tsujimoto S, Nakanishi I, Kinoshita T, Nakamura K, Terasaka T, Nishio N, Sato A, Fujii T. Kuno M, et al. Eur J Pharmacol. 2006 Mar 18;534(1-3):241-9. doi: 10.1016/j.ejphar.2006.01.042. Epub 2006 Mar 3. Eur J Pharmacol. 2006. PMID: 16515782

4

Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism.

Terasaka T, Tsuji K, Kato T, Nakanishi I, Kinoshita T, Kato Y, Kuno M, Inoue T, Tanaka K, Nakamura K. Terasaka T, et al. Among authors: kuno m. J Med Chem. 2005 Jul 28;48(15):4750-3. doi: 10.1021/jm050413g. J Med Chem. 2005. PMID: 16033254

5

Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors.

Terasaka T, Okumura H, Tsuji K, Kato T, Nakanishi I, Kinoshita T, Kato Y, Kuno M, Seki N, Naoe Y, Inoue T, Tanaka K, Nakamura K. Terasaka T, et al. Among authors: kuno m. J Med Chem. 2004 May 20;47(11):2728-31. doi: 10.1021/jm0499559. J Med Chem. 2004. PMID: 15139750

6

Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors.

Terasaka T, Nakanishi I, Nakamura K, Eikyu Y, Kinoshita T, Nishio N, Sato A, Kuno M, Seki N, Sakane K. Terasaka T, et al. Among authors: kuno m. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1115-8. doi: 10.1016/s0960-894x(03)00026-x. Bioorg Med Chem Lett. 2003. PMID: 12643924

7

A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization.

Terasaka T, Kinoshita T, Kuno M, Nakanishi I. Terasaka T, et al. Among authors: kuno m. J Am Chem Soc. 2004 Jan 14;126(1):34-5. doi: 10.1021/ja038606l. J Am Chem Soc. 2004. PMID: 14709046

8

Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.

Terasaka T, Kinoshita T, Kuno M, Seki N, Tanaka K, Nakanishi I. Terasaka T, et al. Among authors: kuno m. J Med Chem. 2004 Jul 15;47(15):3730-43. doi: 10.1021/jm0306374. J Med Chem. 2004. PMID: 15239652

9

Structural basis of compound recognition by adenosine deaminase.

Kinoshita T, Nakanishi I, Terasaka T, Kuno M, Seki N, Warizaya M, Matsumura H, Inoue T, Takano K, Adachi H, Mori Y, Fujii T. Kinoshita T, et al. Among authors: kuno m. Biochemistry. 2005 Aug 9;44(31):10562-9. doi: 10.1021/bi050529e. Biochemistry. 2005. PMID: 16060665

10

Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419.

Tabuchi S, Ito H, Sogabe H, Kuno M, Kinoshita T, Katumi I, Yamamoto N, Mitsui H, Satoh Y. Tabuchi S, et al. Among authors: kuno m. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):1-15. doi: 10.1248/cpb.48.1. Chem Pharm Bull (Tokyo). 2000. PMID: 10705468

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