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Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions.
Gesing A, Masternak MM, Wang F, Joseph AM, Leeuwenburgh C, Westbrook R, Lewinski A, Karbownik-Lewinska M, Bartke A. Gesing A, et al. J Gerontol A Biol Sci Med Sci. 2011 Oct;66(10):1062-76. doi: 10.1093/gerona/glr080. Epub 2011 Jul 25. J Gerontol A Biol Sci Med Sci. 2011. PMID: 21788651 Free PMC article.
Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.
Gesing A, Masternak MM, Lewinski A, Karbownik-Lewinska M, Kopchick JJ, Bartke A. Gesing A, et al. J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):639-51. doi: 10.1093/gerona/gls231. Epub 2012 Nov 29. J Gerontol A Biol Sci Med Sci. 2013. PMID: 23197187 Free PMC article.
96 results