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Page 1
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
Needham LA, Davidson AH, Bawden LJ, Belfield A, Bone EA, Brotherton DH, Bryant S, Charlton MH, Clark VL, Davies SJ, Donald A, Day FA, Krige D, Legris V, McDermott J, McGovern Y, Owen J, Patel SR, Pintat S, Testar RJ, Wells GM, Moffat D, Drummond AH. Needham LA, et al. Among authors: charlton mh. J Pharmacol Exp Ther. 2011 Oct;339(1):132-42. doi: 10.1124/jpet.111.183640. Epub 2011 Jul 21. J Pharmacol Exp Ther. 2011. PMID: 21778281
Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin.
Huertas D, Soler M, Moreto J, Villanueva A, Martinez A, Vidal A, Charlton M, Moffat D, Patel S, McDermott J, Owen J, Brotherton D, Krige D, Cuthill S, Esteller M. Huertas D, et al. Oncogene. 2012 Mar 15;31(11):1408-18. doi: 10.1038/onc.2011.335. Epub 2011 Aug 1. Oncogene. 2012. PMID: 21804608 Free PMC article.
Allosteric inhibition of the neuropeptidase neurolysin.
Hines CS, Ray K, Schmidt JJ, Xiong F, Feenstra RW, Pras-Raves M, de Moes JP, Lange JH, Melikishvili M, Fried MG, Mortenson P, Charlton M, Patel Y, Courtney SM, Kruse CG, Rodgers DW. Hines CS, et al. J Biol Chem. 2014 Dec 19;289(51):35605-19. doi: 10.1074/jbc.M114.620930. Epub 2014 Nov 5. J Biol Chem. 2014. PMID: 25378390 Free PMC article.
The selection and design of GPCR ligands: from concept to the clinic.
Ashton M, Charlton MH, Schwarz MK, Thomas RJ, Whittaker M. Ashton M, et al. Among authors: charlton mh. Comb Chem High Throughput Screen. 2004 Aug;7(5):441-52. doi: 10.2174/1386207043328607. Comb Chem High Throughput Screen. 2004. PMID: 15320711 Review.
N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.
Charlton MH, Aleksis R, Saint-Leger A, Gupta A, Loza E, Ribas de Pouplana L, Kaula I, Gustina D, Madre M, Lola D, Jaudzems K, Edmund G, Randall CP, Kime L, O'Neill AJ, Goessens W, Jirgensons A, Finn PW. Charlton MH, et al. ACS Med Chem Lett. 2018 Jan 18;9(2):84-88. doi: 10.1021/acsmedchemlett.7b00374. eCollection 2018 Feb 8. ACS Med Chem Lett. 2018. PMID: 29456792 Free PMC article.
Structure-activity relationships in 3-isothiazolones.
Morley JO, Oliver Kapur AJ, Charlton MH. Morley JO, et al. Among authors: charlton mh. Org Biomol Chem. 2005 Oct 21;3(20):3713-9. doi: 10.1039/b509529h. Epub 2005 Sep 8. Org Biomol Chem. 2005. PMID: 16211107
29 results