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Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Baumgartner L, Sosa S, Atanasov AG, Bodensieck A, Fakhrudin N, Bauer J, Favero GD, Ponti C, Heiss EH, Schwaiger S, Ladurner A, Widowitz U, Loggia RD, Rollinger JM, Werz O, Bauer R, Dirsch VM, Tubaro A, Stuppner H. Baumgartner L, et al. Among authors: werz o. J Nat Prod. 2011 Aug 26;74(8):1779-86. doi: 10.1021/np200343t. Epub 2011 Jul 29. J Nat Prod. 2011. PMID: 21800856 Free PMC article.
The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: werz o. J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934399
Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor.
Noha SM, Jazzar B, Kuehnl S, Rollinger JM, Stuppner H, Schaible AM, Werz O, Wolber G, Schuster D. Noha SM, et al. Among authors: werz o. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1202-7. doi: 10.1016/j.bmcl.2011.11.093. Epub 2011 Nov 30. Bioorg Med Chem Lett. 2012. PMID: 22192589 Free PMC article.
420 results