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Page 1
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.
Swanson DM, Wong VD, Jablonowski JA, Shah C, Rudolph DA, Dvorak CA, Seierstad M, Dvorak LK, Morton K, Nepomuceno D, Atack JR, Bonaventure P, Lovenberg TW, Carruthers NI. Swanson DM, et al. Among authors: wong vd. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5552-6. doi: 10.1016/j.bmcl.2011.06.136. Epub 2011 Jul 18. Bioorg Med Chem Lett. 2011. PMID: 21802951
The discovery of potent selective NPY Y(2) antagonists.
Chai W, Wong VD, Nepomuceno D, Bonaventure P, Lovenberg TW, Carruthers NI. Chai W, et al. Among authors: wong vd. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4141-4. doi: 10.1016/j.bmcl.2013.05.038. Epub 2013 May 22. Bioorg Med Chem Lett. 2013. PMID: 23756063
Non-imidazole heterocyclic histamine H3 receptor antagonists.
Chai W, Breitenbucher JG, Kwok A, Li X, Wong V, Carruthers NI, Lovenberg TW, Mazur C, Wilson SJ, Axe FU, Jones TK. Chai W, et al. Bioorg Med Chem Lett. 2003 May 19;13(10):1767-70. doi: 10.1016/s0960-894x(03)00299-3. Bioorg Med Chem Lett. 2003. PMID: 12729661
2,4-Thiazolidinediones as potent and selective human beta3 agonists.
Hu B, Ellingboe J, Gunawan I, Han S, Largis E, Li Z, Malamas M, Mulvey R, Oliphant A, Sum FW, Tillett J, Wong V. Hu B, et al. Bioorg Med Chem Lett. 2001 Mar 26;11(6):757-60. doi: 10.1016/s0960-894x(01)00063-4. Bioorg Med Chem Lett. 2001. PMID: 11277513
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Xu G, Liu Z, Wang X, Lu T, DesJarlais RL, Thieu T, Zhang J, Devine ZH, Du F, Li Q, Milligan CM, Shaffer P, Cedervall PE, Spurlino JC, Stratton CF, Pietrak B, Szewczuk LM, Wong V, Steele RA, Bruinzeel W, Chintala M, Silva J, Gaul MD, Macielag MJ, Nargund R. Xu G, et al. J Med Chem. 2022 Aug 11;65(15):10419-10440. doi: 10.1021/acs.jmedchem.2c00442. Epub 2022 Jul 21. J Med Chem. 2022. PMID: 35862732