Lazorchak AS - Search Results

1

Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis.

Lazorchak AS, Su B. Lazorchak AS, et al. Protein Cell. 2011 Jul;2(7):523-30. doi: 10.1007/s13238-011-1077-3. Epub 2011 Aug 6. Protein Cell. 2011. PMID: 21822797 Free PMC article. Review.

2

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.

Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. Lazorchak AS, et al. Mol Cell. 2010 Aug 13;39(3):433-43. doi: 10.1016/j.molcel.2010.07.031. Mol Cell. 2010. PMID: 20705244 Free PMC article.

3

Inhibition of the mTORC2 and chaperone pathways to treat leukemia.

Zhang F, Lazorchak AS, Liu D, Chen F, Su B. Zhang F, et al. Among authors: lazorchak as. Blood. 2012 Jun 21;119(25):6080-8. doi: 10.1182/blood-2011-12-399519. Epub 2012 May 7. Blood. 2012. PMID: 22566604 Free article.

4

Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation.

Chang X, Lazorchak AS, Liu D, Su B. Chang X, et al. Among authors: lazorchak as. Eur J Immunol. 2012 Jun;42(6):1639-47. doi: 10.1002/eji.201142066. Eur J Immunol. 2012. PMID: 22678916 Free PMC article.

5

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.

Li M, Lazorchak AS, Ouyang X, Zhang H, Liu H, Arojo OA, Yan L, Jin J, Han Y, Qu G, Fu Y, Xu X, Liu X, Zhang W, Yang Z, Ruan C, Wang Q, Liu D, Huang C, Lu L, Jiang S, Li F, Su B. Li M, et al. Among authors: lazorchak as. Cell Mol Immunol. 2019 Sep;16(9):757-769. doi: 10.1038/s41423-018-0185-x. Epub 2019 Jan 31. Cell Mol Immunol. 2019. PMID: 30705387 Free PMC article.

6

mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.

Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM, Su B. Wu YT, et al. Among authors: lazorchak as. J Biol Chem. 2011 Apr 22;286(16):14190-8. doi: 10.1074/jbc.M111.219923. Epub 2011 Feb 14. J Biol Chem. 2011. PMID: 21321111 Free PMC article.

7

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Liu P, et al. Among authors: lazorchak as. Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27. Nat Cell Biol. 2013. PMID: 24161930 Free PMC article.

8

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Liu P, et al. Among authors: lazorchak as. Nat Cell Biol. 2019 May;21(5):662-663. doi: 10.1038/s41556-019-0280-y. Nat Cell Biol. 2019. PMID: 30783264

9

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. Facchinetti V, et al. EMBO J. 2008 Jul 23;27(14):1932-43. doi: 10.1038/emboj.2008.120. Epub 2008 Jun 19. EMBO J. 2008. PMID: 18566586 Free PMC article.

10

New insights into E-protein function in lymphocyte development.

Lazorchak A, Jones ME, Zhuang Y. Lazorchak A, et al. Trends Immunol. 2005 Jun;26(6):334-8. doi: 10.1016/j.it.2005.03.011. Trends Immunol. 2005. PMID: 15922950 Review.

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