Qian W - Search Results

1

Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides.

Liu F, Giubellino A, Simister PC, Qian W, Giano MC, Feller SM, Bottaro DP, Burke TR Jr. Liu F, et al. Among authors: qian w. Biopolymers. 2011;96(6):780-8. doi: 10.1002/bip.21692. Biopolymers. 2011. PMID: 21830199 Free PMC article.

2

Investigation of unanticipated alkylation at the N(π) position of a histidyl residue under Mitsunobu conditions and synthesis of orthogonally protected histidine analogues.

Qian W, Liu F, Burke TR Jr. Qian W, et al. J Org Chem. 2011 Nov 4;76(21):8885-90. doi: 10.1021/jo201599c. Epub 2011 Oct 3. J Org Chem. 2011. PMID: 21950469 Free PMC article.

3

Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.

Qian W, Park JE, Liu F, Lee KS, Burke TR Jr. Qian W, et al. Bioorg Med Chem. 2013 Jul 15;21(14):3996-4003. doi: 10.1016/j.bmc.2012.05.036. Epub 2012 May 26. Bioorg Med Chem. 2013. PMID: 22743087 Free PMC article.

4

Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.

Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR Jr. Liu F, et al. ACS Chem Biol. 2012 May 18;7(5):805-10. doi: 10.1021/cb200469a. Epub 2012 Feb 14. ACS Chem Biol. 2012. PMID: 22292814 Free PMC article.

5

Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).

Qian WJ, Park JE, Lee KS, Burke TR Jr. Qian WJ, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7306-8. doi: 10.1016/j.bmcl.2012.10.093. Epub 2012 Oct 27. Bioorg Med Chem Lett. 2012. PMID: 23159568 Free PMC article.

6

Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.

Qian WJ, Burke TR Jr. Qian WJ, et al. Amino Acids. 2013 Nov;45(5):1143-8. doi: 10.1007/s00726-013-1567-0. Epub 2013 Aug 2. Amino Acids. 2013. PMID: 23907438 Free PMC article.

7

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.

Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR Jr. Qian WJ, et al. Biopolymers. 2014 Nov;102(6):444-55. doi: 10.1002/bip.22569. Biopolymers. 2014. PMID: 25283071 Free PMC article.

8

Mitsunobu mischief: neighbor-directed histidine N(τ)-alkylation provides access to peptides containing selectively functionalized imidazolium heterocycles.

Qian WJ, Burke TR Jr. Qian WJ, et al. Org Biomol Chem. 2015 Apr 14;13(14):4221-5. doi: 10.1039/c5ob00171d. Epub 2015 Mar 5. Org Biomol Chem. 2015. PMID: 25739367 Free PMC article.

9

Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.

Qian WJ, Park JE, Grant R, Lai CC, Kelley JA, Yaffe MB, Lee KS, Burke TR Jr. Qian WJ, et al. Biopolymers. 2015 Nov;104(6):663-73. doi: 10.1002/bip.22698. Biopolymers. 2015. PMID: 26152807 Free PMC article.

10

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.

Liu F, Park JE, Qian WJ, Lim D, Gräber M, Berg T, Yaffe MB, Lee KS, Burke TR Jr. Liu F, et al. Nat Chem Biol. 2011 Jul 17;7(9):595-601. doi: 10.1038/nchembio.614. Nat Chem Biol. 2011. PMID: 21765407 Free PMC article.

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