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A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy.
Paredes R, Puertas MC, Bannister W, Kisic M, Cozzi-Lepri A, Pou C, Bellido R, Betancor G, Bogner J, Gargalianos P, Bánhegyi D, Clotet B, Lundgren J, Menéndez-Arias L, Martinez-Picado J; EuroSIDA Study Group. Paredes R, et al. J Infect Dis. 2011 Sep 1;204(5):741-52. doi: 10.1093/infdis/jir385. J Infect Dis. 2011. PMID: 21844300 Free article.
Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation.
Quiñones-Mateu ME, Tadele M, Parera M, Mas A, Weber J, Rangel HR, Chakraborty B, Clotet B, Domingo E, Menéndez-Arias L, Martínez MA. Quiñones-Mateu ME, et al. J Virol. 2002 Oct;76(20):10546-52. doi: 10.1128/jvi.76.20.10546-10552.2002. J Virol. 2002. PMID: 12239335 Free PMC article.
Relative fitness and replication capacity of a multinucleoside analogue-resistant clinical human immunodeficiency virus type 1 isolate with a deletion of codon 69 in the reverse transcriptase coding region.
Villena C, Prado JG, Puertas MC, Martínez MA, Clotet B, Ruiz L, Parkin NT, Menéndez-Arias L, Martinez-Picado J. Villena C, et al. J Virol. 2007 May;81(9):4713-21. doi: 10.1128/JVI.02135-06. Epub 2007 Feb 21. J Virol. 2007. PMID: 17314158 Free PMC article.
HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with virological failure to nucleoside drug combinations.
Garriga C, Pérez-Elías MJ, Delgado R, Ruiz L, Pérez-Alvarez L, Pumarola T, López-Lirola A, González-García J, Menéndez-Arias L; Spanish Group for the Study of Antiretroviral Drug Resistance. Garriga C, et al. J Antimicrob Chemother. 2009 Aug;64(2):251-8. doi: 10.1093/jac/dkp200. Epub 2009 Jun 7. J Antimicrob Chemother. 2009. PMID: 19505892
146 results