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Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.
Drawnel FM, Zhang JD, Küng E, Aoyama N, Benmansour F, Araujo Del Rosario A, Jensen Zoffmann S, Delobel F, Prummer M, Weibel F, Carlson C, Anson B, Iacone R, Certa U, Singer T, Ebeling M, Prunotto M. Drawnel FM, et al. Among authors: singer t. Cell Chem Biol. 2017 May 18;24(5):624-634.e3. doi: 10.1016/j.chembiol.2017.03.016. Epub 2017 Apr 20. Cell Chem Biol. 2017. PMID: 28434878 Free article.
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies.
Flisikowska T, Egli J, Flisikowski K, Stumbaum M, Küng E, Ebeling M, Schmucki R, Georges G, Singer T, Kurome M, Kessler B, Zakhartchenko V, Wolf E, Weber F, Schnieke A, Iglesias A. Flisikowska T, et al. Among authors: singer t. Nat Biomed Eng. 2022 Nov;6(11):1248-1256. doi: 10.1038/s41551-022-00921-2. Epub 2022 Sep 22. Nat Biomed Eng. 2022. PMID: 36138193 Free PMC article.
Characterization of post-surgical alterations in the bile duct-cannulated rat.
Bachir-Cherif D, Blum D, Braendli-Baiocco A, Chaput E, Pacheco GC, Flint N, Haiker M, Hoflack JC, Justies N, Neff R, Starke V, Steiner G, Tournillac CA, Singer T, Ubeaud-Séquier G, Schuler F. Bachir-Cherif D, et al. Among authors: singer t. Xenobiotica. 2011 Aug;41(8):701-11. doi: 10.3109/00498254.2011.565819. Epub 2011 Apr 27. Xenobiotica. 2011. PMID: 21521079
Application of a MABEL Approach for a T-Cell-Bispecific Monoclonal Antibody: CEA TCB.
Dudal S, Hinton H, Giusti AM, Bacac M, Muller M, Fauti T, Colombetti S, Heckel T, Giroud N, Klein C, Umaña P, Benincosa L, Bachl J, Singer T, Bray-French K. Dudal S, et al. Among authors: singer t. J Immunother. 2016 Sep;39(7):279-89. doi: 10.1097/CJI.0000000000000132. J Immunother. 2016. PMID: 27404941
From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.
Braendli-Baiocco A, Festag M, Dumong Erichsen K, Persson R, Mihatsch MJ, Fisker N, Funk J, Mohr S, Constien R, Ploix C, Brady K, Berrera M, Altmann B, Lenz B, Albassam M, Schmitt G, Weiser T, Schuler F, Singer T, Tessier Y. Braendli-Baiocco A, et al. Among authors: singer t. Toxicol Sci. 2017 May 1;157(1):112-128. doi: 10.1093/toxsci/kfx025. Toxicol Sci. 2017. PMID: 28123102 Free PMC article.
685 results