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Functionalisation of brush polyethylene glycol polymers with specific lipids extends their elimination half-life through association with natural lipid trafficking pathways.
Abdallah M, Lin L, Styles IK, Mörsdorf A, Grace JL, Gracia G, Nowell C, Quinn JF, Landersdorfer CB, Whittaker MR, Trevaskis NL. Abdallah M, et al. Acta Biomater. 2024 Jan 15;174:191-205. doi: 10.1016/j.actbio.2023.12.002. Epub 2023 Dec 10. Acta Biomater. 2024. PMID: 38086497 Free article.
TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility.
Rajasekhar P, Carbone SE, Johnston ST, Nowell CJ, Wiklendt L, Crampin EJ, She Y, DiCello JJ, Saito A, Sorensen L, Nguyen T, Lee KM, Hamilton JA, King SK, Eriksson EM, Spencer NJ, Gulbransen BD, Veldhuis NA, Poole DP. Rajasekhar P, et al. Among authors: nowell cj. bioRxiv [Preprint]. 2024 Jan 11:2024.01.09.574831. doi: 10.1101/2024.01.09.574831. bioRxiv. 2024. PMID: 38260314 Free PMC article. Preprint.
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. Boslem E, et al. Sci Adv. 2023 Sep 15;9(37):eadh0831. doi: 10.1126/sciadv.adh0831. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703359 Free PMC article.
Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination.
Le CP, Nowell CJ, Kim-Fuchs C, Botteri E, Hiller JG, Ismail H, Pimentel MA, Chai MG, Karnezis T, Rotmensz N, Renne G, Gandini S, Pouton CW, Ferrari D, Möller A, Stacker SA, Sloan EK. Le CP, et al. Among authors: nowell cj. Nat Commun. 2016 Mar 1;7:10634. doi: 10.1038/ncomms10634. Nat Commun. 2016. PMID: 26925549 Free PMC article.
127 results