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Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Liddle J, Atkinson FL, Barker MD, Carter PS, Curtis NR, Davis RP, Douault C, Dickson MC, Elwes D, Garton NS, Gray M, Hayhow TG, Hobbs CI, Jones E, Leach S, Leavens K, Lewis HD, McCleary S, Neu M, Patel VK, Preston AG, Ramirez-Molina C, Shipley TJ, Skone PA, Smithers N, Somers DO, Walker AL, Watson RJ, Weingarten GG. Liddle J, et al. Among authors: leach s. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94. doi: 10.1016/j.bmcl.2011.07.082. Epub 2011 Aug 12. Bioorg Med Chem Lett. 2011. PMID: 21903390
Managing emerging mutagenicity risks: Late stage mutagenic impurity control within the atovaquone second generation synthesis.
Urquhart MWJ, Bardsley B, Edwards AJ, Giddings A, Griva E, Harvey J, Hermitage S, King F, Leach S, Lesurf C, McKinlay C, Oxley P, Pham TN, Simpson A, Smith E, Stevenson N, Wade C, White A, Wooster N. Urquhart MWJ, et al. Among authors: leach s. Regul Toxicol Pharmacol. 2018 Nov;99:22-32. doi: 10.1016/j.yrtph.2018.08.004. Epub 2018 Aug 15. Regul Toxicol Pharmacol. 2018. PMID: 30118726
828 results