Kalgutkar AS - Search Results

1

Metabolic activation in drug-induced liver injury.

Leung L, Kalgutkar AS, Obach RS. Leung L, et al. Among authors: kalgutkar as. Drug Metab Rev. 2012 Feb;44(1):18-33. doi: 10.3109/03602532.2011.605791. Epub 2011 Sep 23. Drug Metab Rev. 2012. PMID: 21939431 Review.

2

Biotransformation reactions of five-membered aromatic heterocyclic rings.

Dalvie DK, Kalgutkar AS, Khojasteh-Bakht SC, Obach RS, O'Donnell JP. Dalvie DK, et al. Among authors: kalgutkar as. Chem Res Toxicol. 2002 Mar;15(3):269-99. doi: 10.1021/tx015574b. Chem Res Toxicol. 2002. PMID: 11896674 Review. No abstract available.

3

On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics.

Kalgutkar AS, Dalvie DK, O'Donnell JP, Taylor TJ, Sahakian DC. Kalgutkar AS, et al. Curr Drug Metab. 2002 Aug;3(4):379-424. doi: 10.2174/1389200023337360. Curr Drug Metab. 2002. PMID: 12093357 Review.

4

Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.

O'Donnell JP, Dalvie DK, Kalgutkar AS, Obach RS. O'Donnell JP, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2003 Nov;31(11):1369-77. doi: 10.1124/dmd.31.11.1369. Drug Metab Dispos. 2003. PMID: 14570769

5

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4.

Kalgutkar AS, Vaz AD, Lame ME, Henne KR, Soglia J, Zhao SX, Abramov YA, Lombardo F, Collin C, Hendsch ZS, Hop CE. Kalgutkar AS, et al. Drug Metab Dispos. 2005 Feb;33(2):243-53. doi: 10.1124/dmd.104.001735. Epub 2004 Nov 2. Drug Metab Dispos. 2005. PMID: 15523046

6

A comprehensive listing of bioactivation pathways of organic functional groups.

Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE, Dalvie DK, Lee JS, Nakai Y, O'Donnell JP, Boer J, Harriman SP. Kalgutkar AS, et al. Curr Drug Metab. 2005 Jun;6(3):161-225. doi: 10.2174/1389200054021799. Curr Drug Metab. 2005. PMID: 15975040 Review.

7

Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4.

Kalgutkar AS, Henne KR, Lame ME, Vaz AD, Collin C, Soglia JR, Zhao SX, Hop CE. Kalgutkar AS, et al. Chem Biol Interact. 2005 Jun 30;155(1-2):10-20. doi: 10.1016/j.cbi.2005.03.036. Epub 2005 Apr 18. Chem Biol Interact. 2005. PMID: 15978881

8

Minimising the potential for metabolic activation in drug discovery.

Kalgutkar AS, Soglia JR. Kalgutkar AS, et al. Expert Opin Drug Metab Toxicol. 2005 Jun;1(1):91-142. doi: 10.1517/17425255.1.1.91. Expert Opin Drug Metab Toxicol. 2005. PMID: 16922655 Review.

9

Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.

Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV Jr, Soliman VF, Schildknegt K. Kalgutkar AS, et al. Drug Metab Dispos. 2007 Jun;35(6):848-58. doi: 10.1124/dmd.106.013649. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344339

10

Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions.

Kalgutkar AS, Obach RS, Maurer TS. Kalgutkar AS, et al. Curr Drug Metab. 2007 Jun;8(5):407-47. doi: 10.2174/138920007780866807. Curr Drug Metab. 2007. PMID: 17584015 Review.

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