Clark K - Search Results

1

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates.

Liu Y, Beresini MH, Johnson A, Mintzer R, Shah K, Clark K, Schmidt S, Lewis C, Liimatta M, Elliott LO, Gustafson A, Heise CE. Liu Y, et al. Among authors: clark k. J Biomol Screen. 2012 Feb;17(2):225-36. doi: 10.1177/1087057111421525. Epub 2011 Sep 22. J Biomol Screen. 2012. PMID: 21940710

2

Transfer of a protein binding epitope to a minimal designed peptide.

Quan C, Skelton NJ, Clark K, Jackson DY, Renz ME, Chiu HH, Keating SM, Beresini MH, Fong S, Artis DR. Quan C, et al. Among authors: clark k. Biopolymers. 1998;47(4):265-75. doi: 10.1002/(SICI)1097-0282(1998)47:4<265::AID-BIP2>3.0.CO;2-K. Biopolymers. 1998. PMID: 10036968

3

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters JC Jr, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC. Gadek TR, et al. Among authors: clark kr. Science. 2002 Feb 8;295(5557):1086-9. doi: 10.1126/science.295.5557.1086. Science. 2002. PMID: 11834839

4

ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.

Camenisch G, Pisabarro MT, Sherman D, Kowalski J, Nagel M, Hass P, Xie MH, Gurney A, Bodary S, Liang XH, Clark K, Beresini M, Ferrara N, Gerber HP. Camenisch G, et al. Among authors: clark k. J Biol Chem. 2002 May 10;277(19):17281-90. doi: 10.1074/jbc.M109768200. Epub 2002 Feb 27. J Biol Chem. 2002. PMID: 11877390 Free article.

5

Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.

Dubree NJ, Artis DR, Castanedo G, Marsters J, Sutherlin D, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Lowman HB, Skelton NJ, Jackson DY. Dubree NJ, et al. Among authors: clark k. J Med Chem. 2002 Aug 1;45(16):3451-7. doi: 10.1021/jm020033k. J Med Chem. 2002. PMID: 12139455

6

Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.

Castanedo GM, Sailes FC, Dubree NJ, Nicholas JB, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Marsters JC Jr, Jackson DY, Sutherlin DP. Castanedo GM, et al. Among authors: clark k. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2913-7. doi: 10.1016/s0960-894x(02)00597-8. Bioorg Med Chem Lett. 2002. PMID: 12270174

7

N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.

Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR. Burdick DJ, et al. Among authors: clark k. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1015-8. doi: 10.1016/s0960-894x(03)00084-2. Bioorg Med Chem Lett. 2003. PMID: 12643901

8

N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.

Burdick DJ, Marsters JC Jr, Aliagas-Martin I, Stanley M, Beresini M, Clark K, McDowell RS, Gadek TR. Burdick DJ, et al. Among authors: clark k. Bioorg Med Chem Lett. 2004 May 3;14(9):2055-9. doi: 10.1016/j.bmcl.2004.02.046. Bioorg Med Chem Lett. 2004. PMID: 15080978

9

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.

Keating SM, Clark KR, Stefanich LD, Arellano F, Edwards CP, Bodary SC, Spencer SA, Gadek TR, Marsters JC Jr, Beresini MH. Keating SM, et al. Protein Sci. 2006 Feb;15(2):290-303. doi: 10.1110/ps.051583406. Epub 2005 Dec 29. Protein Sci. 2006. PMID: 16384997 Free PMC article.

10

Small-Molecule Library Subset Screening as an Aid for Accelerating Lead Identification.

Beresini MH, Liu Y, Dawes TD, Clark KR, Orren L, Schmidt S, Turincio R, Jones SW, Rodriguez RA, Thana P, Hascall D, Gross DP, Skelton NJ. Beresini MH, et al. J Biomol Screen. 2014 Jun;19(5):758-70. doi: 10.1177/1087057114522515. Epub 2014 Feb 11. J Biomol Screen. 2014. PMID: 24518067

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