Mackenzie GG - Search Results

1

The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine.

Xie G, Nie T, Mackenzie GG, Sun Y, Huang L, Ouyang N, Alston N, Zhu C, Murray OT, Constantinides PP, Kopelovich L, Rigas B. Xie G, et al. Among authors: mackenzie gg. Br J Pharmacol. 2012 Apr;165(7):2152-66. doi: 10.1111/j.1476-5381.2011.01705.x. Br J Pharmacol. 2012. PMID: 21955327 Free PMC article.

2

NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis?

Mackenzie GG, Rasheed S, Wertheim W, Rigas B. Mackenzie GG, et al. PPAR Res. 2008;2008:919572. doi: 10.1155/2008/919572. PPAR Res. 2008. PMID: 18528523 Free PMC article.

3

Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect.

Zhao W, Mackenzie GG, Murray OT, Zhang Z, Rigas B. Zhao W, et al. Among authors: mackenzie gg. Carcinogenesis. 2009 Mar;30(3):512-9. doi: 10.1093/carcin/bgp015. Epub 2009 Jan 9. Carcinogenesis. 2009. PMID: 19136474 Free PMC article.

4

The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin.

Hua A, Mackenzie GG, Rigas B. Hua A, et al. Among authors: mackenzie gg. Int J Oncol. 2009 Oct;35(4):837-44. doi: 10.3892/ijo_00000397. Int J Oncol. 2009. PMID: 19724920 Free PMC article.

5

Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.

Mackenzie GG, Sun Y, Huang L, Xie G, Ouyang N, Gupta RC, Johnson F, Komninou D, Kopelovich L, Rigas B. Mackenzie GG, et al. Gastroenterology. 2010 Oct;139(4):1320-32. doi: 10.1053/j.gastro.2010.06.044. Epub 2010 Jun 20. Gastroenterology. 2010. PMID: 20600034 Free PMC article.

6

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.

Huang L, Zhu C, Sun Y, Xie G, Mackenzie GG, Qiao G, Komninou D, Rigas B. Huang L, et al. Among authors: mackenzie gg. Carcinogenesis. 2010 Nov;31(11):1982-90. doi: 10.1093/carcin/bgq149. Epub 2010 Jul 12. Carcinogenesis. 2010. PMID: 20627873 Free PMC article.

7

Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models.

Xie G, Sun Y, Nie T, Mackenzie GG, Huang L, Kopelovich L, Komninou D, Rigas B. Xie G, et al. Among authors: mackenzie gg. J Pharmacol Exp Ther. 2011 Jun;337(3):876-86. doi: 10.1124/jpet.111.180224. Epub 2011 Mar 21. J Pharmacol Exp Ther. 2011. PMID: 21422165 Free PMC article.

8

Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.

Mackenzie GG, Ouyang N, Xie G, Vrankova K, Huang L, Sun Y, Komninou D, Kopelovich L, Rigas B. Mackenzie GG, et al. Cancer Prev Res (Phila). 2011 Jul;4(7):1052-60. doi: 10.1158/1940-6207.CAPR-11-0067. Epub 2011 Apr 4. Cancer Prev Res (Phila). 2011. PMID: 21464038 Free PMC article.

9

Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents.

Sun Y, Huang L, Mackenzie GG, Rigas B. Sun Y, et al. Among authors: mackenzie gg. J Pharmacol Exp Ther. 2011 Sep;338(3):775-83. doi: 10.1124/jpet.111.183533. Epub 2011 Jun 6. J Pharmacol Exp Ther. 2011. PMID: 21646387 Free PMC article.

10

Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds.

Huang L, Mackenzie GG, Sun Y, Ouyang N, Xie G, Vrankova K, Komninou D, Rigas B. Huang L, et al. Among authors: mackenzie gg. Cancer Res. 2011 Dec 15;71(24):7617-27. doi: 10.1158/0008-5472.CAN-11-2349. Epub 2011 Oct 24. Cancer Res. 2011. PMID: 22025561 Free PMC article.

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