Hruz PW - Search Results

1

HIV protease inhibitors act as competitive inhibitors of the cytoplasmic glucose binding site of GLUTs with differing affinities for GLUT1 and GLUT4.

Hresko RC, Hruz PW. Hresko RC, et al. Among authors: hruz pw. PLoS One. 2011;6(9):e25237. doi: 10.1371/journal.pone.0025237. Epub 2011 Sep 23. PLoS One. 2011. PMID: 21966466 Free PMC article.

2

The mechanism of insulin resistance caused by HIV protease inhibitor therapy.

Murata H, Hruz PW, Mueckler M. Murata H, et al. Among authors: hruz pw. J Biol Chem. 2000 Jul 7;275(27):20251-4. doi: 10.1074/jbc.C000228200. J Biol Chem. 2000. PMID: 10806189 Free article.

3

Indinavir induces acute and reversible peripheral insulin resistance in rats.

Hruz PW, Murata H, Qiu H, Mueckler M. Hruz PW, et al. Diabetes. 2002 Apr;51(4):937-42. doi: 10.2337/diabetes.51.4.937. Diabetes. 2002. PMID: 11916910

4

Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations.

Murata H, Hruz PW, Mueckler M. Murata H, et al. Among authors: hruz pw. AIDS. 2002 Apr 12;16(6):859-63. doi: 10.1097/00002030-200204120-00005. AIDS. 2002. PMID: 11919487

5

Investigating the cellular targets of HIV protease inhibitors: implications for metabolic disorders and improvements in drug therapy.

Murata H, Hruz PW, Mueckler M. Murata H, et al. Among authors: hruz pw. Curr Drug Targets Infect Disord. 2002 Mar;2(1):1-8. doi: 10.2174/1568005024605882. Curr Drug Targets Infect Disord. 2002. PMID: 12462148 Review.

6

HIV protease inhibitors acutely impair glucose-stimulated insulin release.

Koster JC, Remedi MS, Qiu H, Nichols CG, Hruz PW. Koster JC, et al. Among authors: hruz pw. Diabetes. 2003 Jul;52(7):1695-1700. doi: 10.2337/diabetes.52.7.1695. Diabetes. 2003. PMID: 12829635 Free PMC article.

7

A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity.

Hertel J, Struthers H, Horj CB, Hruz PW. Hertel J, et al. Among authors: hruz pw. J Biol Chem. 2004 Dec 31;279(53):55147-52. doi: 10.1074/jbc.M410826200. Epub 2004 Oct 20. J Biol Chem. 2004. PMID: 15496402 Free PMC article.

8

Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal.

Yan Q, Hruz PW. Yan Q, et al. Among authors: hruz pw. J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):398-403. doi: 10.1097/01.qai.0000176654.97392.c7. J Acquir Immune Defic Syndr. 2005. PMID: 16280693 Free PMC article.

9

HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy.

Hruz PW, Yan Q, Struthers H, Jay PY. Hruz PW, et al. FASEB J. 2008 Jul;22(7):2161-7. doi: 10.1096/fj.07-102269. Epub 2008 Feb 6. FASEB J. 2008. PMID: 18256305

10

Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice.

Vyas AK, Koster JC, Tzekov A, Hruz PW. Vyas AK, et al. Among authors: hruz pw. J Biol Chem. 2010 Nov 19;285(47):36395-400. doi: 10.1074/jbc.M110.176321. Epub 2010 Sep 23. J Biol Chem. 2010. PMID: 20864532 Free PMC article.

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