Sakai N - Search Results

1

Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.

Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H. Shuvaev AN, et al. Among authors: sakai n. J Neurosci. 2011 Oct 5;31(40):14324-34. doi: 10.1523/JNEUROSCI.5530-10.2011. J Neurosci. 2011. PMID: 21976518 Free PMC article.

2

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.

Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N. Takahashi H, et al. Among authors: sakai n. Hum Mol Genet. 2015 Jan 15;24(2):525-39. doi: 10.1093/hmg/ddu472. Epub 2014 Sep 12. Hum Mol Genet. 2015. PMID: 25217572

3

Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death.

Seki T, Adachi N, Ono Y, Mochizuki H, Hiramoto K, Amano T, Matsubayashi H, Matsumoto M, Kawakami H, Saito N, Sakai N. Seki T, et al. Among authors: sakai n. J Biol Chem. 2005 Aug 12;280(32):29096-106. doi: 10.1074/jbc.M501716200. Epub 2005 Jun 17. J Biol Chem. 2005. PMID: 15964845 Free article.

4

Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4.

Hiramoto K, Kawakami H, Inoue K, Seki T, Maruyama H, Morino H, Matsumoto M, Kurisu K, Sakai N. Hiramoto K, et al. Among authors: sakai n. Mov Disord. 2006 Sep;21(9):1355-60. doi: 10.1002/mds.20970. Mov Disord. 2006. PMID: 16763984

5

Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress.

Seki T, Takahashi H, Adachi N, Abe N, Shimahara T, Saito N, Sakai N. Seki T, et al. Among authors: sakai n. Eur J Neurosci. 2007 Dec;26(11):3126-40. doi: 10.1111/j.1460-9568.2007.05933.x. Epub 2007 Nov 14. Eur J Neurosci. 2007. PMID: 18005063

6

Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells.

Seki T, Shimahara T, Yamamoto K, Abe N, Amano T, Adachi N, Takahashi H, Kashiwagi K, Saito N, Sakai N. Seki T, et al. Among authors: sakai n. Neurobiol Dis. 2009 Feb;33(2):260-73. doi: 10.1016/j.nbd.2008.10.013. Epub 2008 Nov 8. Neurobiol Dis. 2009. PMID: 19041943

7

Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy.

Yamamoto K, Seki T, Adachi N, Takahashi T, Tanaka S, Hide I, Saito N, Sakai N. Yamamoto K, et al. Among authors: sakai n. Genes Cells. 2010 May;15(5):425-38. doi: 10.1111/j.1365-2443.2010.01395.x. Epub 2010 Apr 11. Genes Cells. 2010. PMID: 20398063 Free article.

8

Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells.

Seki T, Abe-Seki N, Kikawada T, Takahashi H, Yamamoto K, Adachi N, Tanaka S, Hide I, Saito N, Sakai N. Seki T, et al. Among authors: sakai n. J Biol Chem. 2010 Oct 22;285(43):33252-33264. doi: 10.1074/jbc.M110.146704. Epub 2010 Aug 12. J Biol Chem. 2010. PMID: 20705605 Free PMC article.

9

Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase cγ that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation.

Seki T, Takahashi H, Yamamoto K, Ogawa K, Onji T, Adachi N, Tanaka S, Hide I, Saito N, Sakai N. Seki T, et al. Among authors: sakai n. J Pharmacol Sci. 2010;114(2):206-16. doi: 10.1254/jphs.10170fp. J Pharmacol Sci. 2010. PMID: 20938103 Free article.

10

Elucidation of the molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant protein kinase Cγ.

Seki T, Adachi N, Abe-Seki N, Shimahara T, Takahashi H, Yamamoto K, Saito N, Sakai N. Seki T, et al. Among authors: sakai n. J Pharmacol Sci. 2011;116(3):239-47. doi: 10.1254/jphs.11r04cp. Epub 2011 Jun 10. J Pharmacol Sci. 2011. PMID: 21666345 Free article. Review.

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