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Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism.
Steppan J, Ryoo S, Schuleri KH, Gregg C, Hasan RK, White AR, Bugaj LJ, Khan M, Santhanam L, Nyhan D, Shoukas AA, Hare JM, Berkowitz DE. Steppan J, et al. Among authors: santhanam l. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64. doi: 10.1073/pnas.0506589103. Epub 2006 Mar 13. Proc Natl Acad Sci U S A. 2006. PMID: 16537391 Free PMC article.
Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction.
Santhanam L, Lim HK, Lim HK, Miriel V, Brown T, Patel M, Balanson S, Ryoo S, Anderson M, Irani K, Khanday F, Di Costanzo L, Nyhan D, Hare JM, Christianson DW, Rivers R, Shoukas A, Berkowitz DE. Santhanam L, et al. Circ Res. 2007 Sep 28;101(7):692-702. doi: 10.1161/CIRCRESAHA.107.157727. Epub 2007 Aug 17. Circ Res. 2007. PMID: 17704205
Endothelial arginase II: a novel target for the treatment of atherosclerosis.
Ryoo S, Gupta G, Benjo A, Lim HK, Camara A, Sikka G, Lim HK, Sohi J, Santhanam L, Soucy K, Tuday E, Baraban E, Ilies M, Gerstenblith G, Nyhan D, Shoukas A, Christianson DW, Alp NJ, Champion HC, Huso D, Berkowitz DE. Ryoo S, et al. Among authors: santhanam l. Circ Res. 2008 Apr 25;102(8):923-32. doi: 10.1161/CIRCRESAHA.107.169573. Epub 2008 Feb 28. Circ Res. 2008. PMID: 18309100
Arginase and vascular aging.
Santhanam L, Christianson DW, Nyhan D, Berkowitz DE. Santhanam L, et al. J Appl Physiol (1985). 2008 Nov;105(5):1632-42. doi: 10.1152/japplphysiol.90627.2008. Epub 2008 Aug 21. J Appl Physiol (1985). 2008. PMID: 18719233 Free PMC article. Review.
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.
Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE. Kim JH, et al. Among authors: santhanam l. J Appl Physiol (1985). 2009 Oct;107(4):1249-57. doi: 10.1152/japplphysiol.91393.2008. Epub 2009 Aug 6. J Appl Physiol (1985). 2009. PMID: 19661445 Free PMC article.
Acute inhibition of both NOS, with N(G)-nitro-l-arginine methyl ester, and arginase, with 2S-amino- 6-boronohexanoic acid (ABH), significantly reduced O2(-) production in old rats but not in young. ...These findings support our previously published finding that iNOS nitros …
Acute inhibition of both NOS, with N(G)-nitro-l-arginine methyl ester, and arginase, with 2S-amino- 6-boronohexanoic acid (ABH), sign …
92 results