Grunwald C - Search Results

1

Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.

Malamas MS, Ni Y, Erdei J, Stange H, Schindler R, Lankau HJ, Grunwald C, Fan KY, Parris K, Langen B, Egerland U, Hage T, Marquis KL, Grauer S, Brennan J, Navarra R, Graf R, Harrison BL, Robichaud A, Kronbach T, Pangalos MN, Hoefgen N, Brandon NJ. Malamas MS, et al. Among authors: grunwald c. J Med Chem. 2011 Nov 10;54(21):7621-38. doi: 10.1021/jm2009138. Epub 2011 Oct 11. J Med Chem. 2011. PMID: 21988093

2

Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.

Höfgen N, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Tremmel P, Pangalos MN, Marquis KL, Hage T, Harrison BL, Malamas MS, Brandon NJ, Kronbach T. Höfgen N, et al. Among authors: grunwald c. J Med Chem. 2010 Jun 10;53(11):4399-411. doi: 10.1021/jm1002793. J Med Chem. 2010. PMID: 20450197

3

Novel triazines as potent and selective phosphodiesterase 10A inhibitors.

Malamas MS, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Hage T, Ni Y, Erdei J, Fan KY, Parris K, Marquis KL, Grauer S, Brennan J, Navarra R, Graf R, Harrison BL, Robichaud A, Kronbach T, Pangalos MN, Brandon NJ, Hoefgen N. Malamas MS, et al. Among authors: grunwald c. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5876-84. doi: 10.1016/j.bmcl.2012.07.076. Epub 2012 Jul 31. Bioorg Med Chem Lett. 2012. PMID: 22902656

4

Discovery of triazines as potent, selective and orally active PDE4 inhibitors.

Gewald R, Grunwald C, Egerland U. Gewald R, et al. Among authors: grunwald c. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4308-14. doi: 10.1016/j.bmcl.2013.05.099. Epub 2013 Jun 10. Bioorg Med Chem Lett. 2013. PMID: 23806553

5

Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors.

Gewald R, Rueger C, Grunwald C, Egerland U, Hoefgen N. Gewald R, et al. Among authors: grunwald c. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6652-6. doi: 10.1016/j.bmcl.2011.09.065. Epub 2011 Sep 21. Bioorg Med Chem Lett. 2011. PMID: 21983442

6

Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

Grunwald C, Rundfeldt C, Lankau HJ, Arnold T, Höfgen N, Dost R, Egerland U, Hofmann HJ, Unverferth K. Grunwald C, et al. J Med Chem. 2006 Mar 23;49(6):1855-66. doi: 10.1021/jm0509400. J Med Chem. 2006. PMID: 16539371

7

New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity.

Lankau HJ, Unverferth K, Grunwald C, Hartenhauer H, Heinecke K, Bernöster K, Dost R, Egerland U, Rundfeldt C. Lankau HJ, et al. Among authors: grunwald c. Eur J Med Chem. 2007 Jun;42(6):873-9. doi: 10.1016/j.ejmech.2006.12.022. Epub 2007 Jan 12. Eur J Med Chem. 2007. PMID: 17303289

8

5-(4-Hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-2,3,6,7-tetrahydro-1,4-thiazepines as compounds with high affinity at the benzodiazepine binding site on GABA(A) receptors.

Grunwald C, Kronbach C, Egerland U, Schindler R, Dieckmann R, Heinecke K, Höfgen N, Unverferth K. Grunwald C, et al. Pharmazie. 2011 Feb;66(2):98-104. doi: 10.1002/chin.201125210. Pharmazie. 2011. PMID: 21434570

9

Large-scale mining for similar protein binding pockets: with RAPMAD retrieval on the fly becomes real.

Krotzky T, Grunwald C, Egerland U, Klebe G. Krotzky T, et al. Among authors: grunwald c. J Chem Inf Model. 2015 Jan 26;55(1):165-79. doi: 10.1021/ci5005898. Epub 2014 Dec 18. J Chem Inf Model. 2015. PMID: 25474400

10

Metabolism of retigabine (D-23129), a novel anticonvulsant.

Hempel R, Schupke H, McNeilly PJ, Heinecke K, Kronbach C, Grunwald C, Zimmermann G, Griesinger C, Engel J, Kronbach T. Hempel R, et al. Among authors: grunwald c. Drug Metab Dispos. 1999 May;27(5):613-22. Drug Metab Dispos. 1999. PMID: 10220491

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