Kronbach T - Search Results

1

Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.

Malamas MS, Ni Y, Erdei J, Stange H, Schindler R, Lankau HJ, Grunwald C, Fan KY, Parris K, Langen B, Egerland U, Hage T, Marquis KL, Grauer S, Brennan J, Navarra R, Graf R, Harrison BL, Robichaud A, Kronbach T, Pangalos MN, Hoefgen N, Brandon NJ. Malamas MS, et al. Among authors: kronbach t. J Med Chem. 2011 Nov 10;54(21):7621-38. doi: 10.1021/jm2009138. Epub 2011 Oct 11. J Med Chem. 2011. PMID: 21988093

2

Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.

Höfgen N, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Tremmel P, Pangalos MN, Marquis KL, Hage T, Harrison BL, Malamas MS, Brandon NJ, Kronbach T. Höfgen N, et al. Among authors: kronbach t. J Med Chem. 2010 Jun 10;53(11):4399-411. doi: 10.1021/jm1002793. J Med Chem. 2010. PMID: 20450197

3

Novel triazines as potent and selective phosphodiesterase 10A inhibitors.

Malamas MS, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Hage T, Ni Y, Erdei J, Fan KY, Parris K, Marquis KL, Grauer S, Brennan J, Navarra R, Graf R, Harrison BL, Robichaud A, Kronbach T, Pangalos MN, Brandon NJ, Hoefgen N. Malamas MS, et al. Among authors: kronbach t. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5876-84. doi: 10.1016/j.bmcl.2012.07.076. Epub 2012 Jul 31. Bioorg Med Chem Lett. 2012. PMID: 22902656

4

In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration.

Kuss H, Hoefgen N, Johanssen S, Kronbach T, Rundfeldt C. Kuss H, et al. Among authors: kronbach t. J Pharmacol Exp Ther. 2003 Oct;307(1):373-85. doi: 10.1124/jpet.103.053942. Epub 2003 Aug 27. J Pharmacol Exp Ther. 2003. PMID: 12944497

5

Refolding, purification, and characterization of human recombinant PDE4A constructs expressed in Escherichia coli.

Richter W, Hermsdorf T, Lilie H, Egerland U, Rudolph R, Kronbach T, Dettmer D. Richter W, et al. Among authors: kronbach t. Protein Expr Purif. 2000 Aug;19(3):375-83. doi: 10.1006/prep.2000.1260. Protein Expr Purif. 2000. PMID: 10910728

6

Metabolism of retigabine (D-23129), a novel anticonvulsant.

Hempel R, Schupke H, McNeilly PJ, Heinecke K, Kronbach C, Grunwald C, Zimmermann G, Griesinger C, Engel J, Kronbach T. Hempel R, et al. Among authors: kronbach c, kronbach t. Drug Metab Dispos. 1999 May;27(5):613-22. Drug Metab Dispos. 1999. PMID: 10220491

7

Refolding and purification of recombinant human PDE7A expressed in Escherichia coli as inclusion bodies.

Richter W, Hermsdorf T, Kronbach T, Dettmer D. Richter W, et al. Among authors: kronbach t. Protein Expr Purif. 2002 Jun;25(1):138-48. doi: 10.1006/prep.2002.1620. Protein Expr Purif. 2002. PMID: 12071709

8

Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis.

Richter W, Unciuleac L, Hermsdorf T, Kronbach T, Dettmer D. Richter W, et al. Among authors: kronbach t. Cell Signal. 2001 Mar;13(3):159-67. doi: 10.1016/s0898-6568(01)00142-5. Cell Signal. 2001. PMID: 11282454

9

Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4.

Richter W, Unciuleac L, Hermsdorf T, Kronbach T, Dettmer D. Richter W, et al. Among authors: kronbach t. Cell Signal. 2001 Apr;13(4):287-97. doi: 10.1016/s0898-6568(01)00150-4. Cell Signal. 2001. PMID: 11306246

10

Purification and characterization of recombinant-expressed cytochrome P450 2C3 from Escherichia coli: 2C3 encodes the 6 beta-hydroxylase deficient form of P450 3b.

Richardson TH, Hsu MH, Kronbach T, Barnes HJ, Chan G, Waterman MR, Kemper B, Johnson EF. Richardson TH, et al. Among authors: kronbach t. Arch Biochem Biophys. 1993 Jan;300(1):510-6. doi: 10.1006/abbi.1993.1069. Arch Biochem Biophys. 1993. PMID: 8380971

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