Strachan RT - Search Results

1

Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.

Lin R, Degan S, Theriot BS, Fischer BM, Strachan RT, Liang J, Pierce RA, Sunday ME, Noble PW, Kraft M, Brody AR, Walker JK. Lin R, et al. Among authors: strachan rt. Br J Pharmacol. 2012 Apr;165(7):2365-77. doi: 10.1111/j.1476-5381.2011.01725.x. Br J Pharmacol. 2012. PMID: 22013997 Free PMC article.

2

Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.

Hegde A, Strachan RT, Walker JK. Hegde A, et al. Among authors: strachan rt. PLoS One. 2015 Feb 6;10(2):e0116458. doi: 10.1371/journal.pone.0116458. eCollection 2015. PLoS One. 2015. PMID: 25658948 Free PMC article.

3

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ. Staus DP, et al. Among authors: strachan rt. Mol Pharmacol. 2014 Mar;85(3):472-81. doi: 10.1124/mol.113.089516. Epub 2013 Dec 6. Mol Pharmacol. 2014. PMID: 24319111 Free PMC article.

4

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.

Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ. Kahsai AW, et al. Among authors: strachan rt. Nat Chem Biol. 2016 Sep;12(9):709-16. doi: 10.1038/nchembio.2126. Epub 2016 Jul 11. Nat Chem Biol. 2016. PMID: 27398998 Free PMC article.

5

Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.

Jean-Charles PY, Yu SM, Abraham D, Kommaddi RP, Mao L, Strachan RT, Zhang ZS, Bowles DE, Brian L, Stiber JA, Jones SN, Koch WJ, Rockman HA, Shenoy SK. Jean-Charles PY, et al. Among authors: strachan rt. JCI Insight. 2017 Sep 7;2(17):e95998. doi: 10.1172/jci.insight.95998. eCollection 2017 Sep 7. JCI Insight. 2017. PMID: 28878120 Free PMC article.

6

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. Hara MR, et al. Among authors: strachan rt. Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. Nature. 2011. PMID: 21857681 Free PMC article.

7

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ. Nobles KN, et al. Among authors: strachan rt. Sci Signal. 2011 Aug 9;4(185):ra51. doi: 10.1126/scisignal.2001707. Sci Signal. 2011. PMID: 21868357 Free PMC article.

8

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.

Pironti G, Strachan RT, Abraham D, Mon-Wei Yu S, Chen M, Chen W, Hanada K, Mao L, Watson LJ, Rockman HA. Pironti G, et al. Among authors: strachan rt. Circulation. 2015 Jun 16;131(24):2120-30. doi: 10.1161/CIRCULATIONAHA.115.015687. Epub 2015 May 20. Circulation. 2015. PMID: 25995315 Free PMC article.

9

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ. Ahn S, et al. Among authors: strachan rt. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27. Proc Natl Acad Sci U S A. 2017. PMID: 28130548 Free PMC article.

10

Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.

Tang W, Strachan RT, Lefkowitz RJ, Rockman HA. Tang W, et al. Among authors: strachan rt. J Biol Chem. 2014 Oct 10;289(41):28271-83. doi: 10.1074/jbc.M114.585067. Epub 2014 Aug 28. J Biol Chem. 2014. PMID: 25170081 Free PMC article.

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