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Page 1
Structural nucleotide analogs are potent activators/inhibitors of pancreatic β cell KATP channels: an emerging mechanism supporting their use as antidiabetic drugs.
Tricarico D, Rolland JF, Cannone G, Mele A, Cippone V, Laghezza A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Conte Camerino D. Tricarico D, et al. Among authors: carbonara g. J Pharmacol Exp Ther. 2012 Feb;340(2):266-76. doi: 10.1124/jpet.111.185835. Epub 2011 Oct 25. J Pharmacol Exp Ther. 2012. PMID: 22028392
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels.
Tricarico D, Mele A, Camerino GM, Laghezza A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Camerino DC. Tricarico D, et al. Among authors: carbonara g. Mol Pharmacol. 2008 Jul;74(1):50-8. doi: 10.1124/mol.108.046615. Epub 2008 Apr 10. Mol Pharmacol. 2008. PMID: 18403717
Activation and inhibition of kidney CLC-K chloride channels by fenamates.
Liantonio A, Picollo A, Babini E, Carbonara G, Fracchiolla G, Loiodice F, Tortorella V, Pusch M, Camerino DC. Liantonio A, et al. Among authors: carbonara g. Mol Pharmacol. 2006 Jan;69(1):165-73. doi: 10.1124/mol.105.017384. Epub 2005 Oct 21. Mol Pharmacol. 2006. PMID: 16244177
Molecular switch for CLC-K Cl- channel block/activation: optimal pharmacophoric requirements towards high-affinity ligands.
Liantonio A, Picollo A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Laghezza A, Babini E, Zifarelli G, Pusch M, Camerino DC. Liantonio A, et al. Among authors: carbonara g. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1369-73. doi: 10.1073/pnas.0708977105. Epub 2008 Jan 23. Proc Natl Acad Sci U S A. 2008. PMID: 18216243 Free PMC article.
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Fracchiolla G, Lavecchia A, Laghezza A, Piemontese L, Trisolini R, Carbonara G, Tortorella P, Novellino E, Loiodice F. Fracchiolla G, et al. Among authors: carbonara g. Bioorg Med Chem. 2008 Nov 1;16(21):9498-510. doi: 10.1016/j.bmc.2008.09.045. Epub 2008 Sep 19. Bioorg Med Chem. 2008. PMID: 18835719
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.
Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S, Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F. Piemontese L, et al. Among authors: carbonara g. Eur J Med Chem. 2015 Jan 27;90:583-94. doi: 10.1016/j.ejmech.2014.11.044. Epub 2014 Nov 24. Eur J Med Chem. 2015. PMID: 25497132
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
Fracchiolla G, Laghezza A, Piemontese L, Parente M, Lavecchia A, Pochetti G, Montanari R, Di Giovanni C, Carbonara G, Tortorella P, Novellino E, Loiodice F. Fracchiolla G, et al. Among authors: carbonara g. Bioorg Med Chem. 2012 Mar 15;20(6):2141-51. doi: 10.1016/j.bmc.2012.01.025. Epub 2012 Jan 28. Bioorg Med Chem. 2012. PMID: 22341573
36 results