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Structural nucleotide analogs are potent activators/inhibitors of pancreatic β cell KATP channels: an emerging mechanism supporting their use as antidiabetic drugs.
Tricarico D, Rolland JF, Cannone G, Mele A, Cippone V, Laghezza A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Conte Camerino D. Tricarico D, et al. Among authors: tortorella p. J Pharmacol Exp Ther. 2012 Feb;340(2):266-76. doi: 10.1124/jpet.111.185835. Epub 2011 Oct 25. J Pharmacol Exp Ther. 2012. PMID: 22028392
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of an aryloxyalkyl group alpha to the carboxylic function of 4-chloro-phenoxyacetic acid.
Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Conte-Camerino D, De Luca A, Liantonio A. Carbonara G, et al. Among authors: tortorella p. Farmaco. 2001 Oct;56(10):749-54. doi: 10.1016/s0014-827x(01)01127-2. Farmaco. 2001. PMID: 11718267
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo.
Talon S, De Luca A, De Bellis M, Desaphy JF, Lentini G, Scilimati A, Corbo F, Franchini C, Tortorella P, Jockusch H, Conte Camerino D. Talon S, et al. Among authors: tortorella p. Br J Pharmacol. 2001 Dec;134(7):1523-31. doi: 10.1038/sj.bjp.0704366. Br J Pharmacol. 2001. PMID: 11724759 Free PMC article.
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.
Liantonio A, De Luca A, Pierno S, Didonna MP, Loiodice F, Fracchiolla G, Tortorella P, Antonio L, Bonerba E, Traverso S, Elia L, Picollo A, Pusch M, Camerino DC. Liantonio A, et al. Among authors: tortorella p. Br J Pharmacol. 2003 Aug;139(7):1255-64. doi: 10.1038/sj.bjp.0705364. Br J Pharmacol. 2003. PMID: 12890704 Free PMC article.
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers.
Liantonio A, Pusch M, Picollo A, Guida P, De Luca A, Pierno S, Fracchiolla G, Loiodice F, Tortorella P, Conte Camerino D. Liantonio A, et al. Among authors: tortorella p. J Am Soc Nephrol. 2004 Jan;15(1):13-20. doi: 10.1097/01.asn.0000103226.28798.ea. J Am Soc Nephrol. 2004. PMID: 14694153
126 results