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PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.
Carnevale D, Vecchione C, Mascio G, Esposito G, Cifelli G, Martinello K, Landolfi A, Selvetella G, Grieco P, Damato A, Franco E, Haase H, Maffei A, Ciraolo E, Fucile S, Frati G, Mazzoni O, Hirsch E, Lembo G. Carnevale D, et al. Among authors: cifelli g. Cardiovasc Res. 2012 Jan 1;93(1):200-9. doi: 10.1093/cvr/cvr288. Epub 2011 Oct 27. Cardiovasc Res. 2012. PMID: 22038741
PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice.
Maffei A, Cifelli G, Carnevale R, Iacobucci R, Pallante F, Fardella V, Fardella S, Hirsch E, Lembo G, Carnevale D. Maffei A, et al. Among authors: cifelli g. Rev Esp Cardiol (Engl Ed). 2017 Jan;70(1):16-24. doi: 10.1016/j.rec.2016.04.034. Epub 2016 Jul 13. Rev Esp Cardiol (Engl Ed). 2017. PMID: 27422446 English, Spanish.
Resistin impairs insulin-evoked vasodilation.
Gentile MT, Vecchione C, Marino G, Aretini A, Di Pardo A, Antenucci G, Maffei A, Cifelli G, Iorio L, Landolfi A, Frati G, Lembo G. Gentile MT, et al. Among authors: cifelli g. Diabetes. 2008 Mar;57(3):577-83. doi: 10.2337/db07-0557. Epub 2007 Dec 7. Diabetes. 2008. PMID: 18065520
Tumor necrosis factor-alpha mediates hemolysis-induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage.
Vecchione C, Frati A, Di Pardo A, Cifelli G, Carnevale D, Gentile MT, Carangi R, Landolfi A, Carullo P, Bettarini U, Antenucci G, Mascio G, Busceti CL, Notte A, Maffei A, Cantore GP, Lembo G. Vecchione C, et al. Among authors: cifelli g. Hypertension. 2009 Jul;54(1):150-6. doi: 10.1161/HYPERTENSIONAHA.108.128124. Epub 2009 May 26. Hypertension. 2009. PMID: 19470883
Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-α-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload.
Carnevale D, Cifelli G, Mascio G, Madonna M, Sbroggiò M, Perrino C, Persico MG, Frati G, Lembo G. Carnevale D, et al. Among authors: cifelli g. Circulation. 2011 Sep 20;124(12):1337-50. doi: 10.1161/CIRCULATIONAHA.111.050500. Epub 2011 Sep 6. Circulation. 2011. PMID: 21900081
Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure.
Litteri G, Carnevale D, D'Urso A, Cifelli G, Braghetta P, Damato A, Bizzotto D, Landolfi A, Ros FD, Sabatelli P, Facchinello N, Maffei A, Volpin D, Colombatti A, Bressan GM, Lembo G. Litteri G, et al. Among authors: cifelli g. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2178-84. doi: 10.1161/ATVBAHA.112.254664. Epub 2012 Jul 19. Arterioscler Thromb Vasc Biol. 2012. PMID: 22814752
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