Yang T - Search Results

1

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.

Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Hong S, et al. Among authors: yang t. J Neurosci. 2011 Nov 2;31(44):15861-9. doi: 10.1523/JNEUROSCI.3272-11.2011. J Neurosci. 2011. PMID: 22049429 Free PMC article.

2

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.

Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. Yang T, et al. Alzheimers Dement. 2013 Mar;9(2):99-112. doi: 10.1016/j.jalz.2012.11.005. Epub 2013 Jan 30. Alzheimers Dement. 2013. PMID: 23375565 Free PMC article.

3

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ. Hong S, et al. Among authors: yang t. Neuron. 2014 Apr 16;82(2):308-19. doi: 10.1016/j.neuron.2014.02.027. Epub 2014 Mar 27. Neuron. 2014. PMID: 24685176 Free PMC article.

4

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers.

Xu H, Gelyana E, Rajsombath M, Yang T, Li S, Selkoe D. Xu H, et al. Among authors: yang t. J Neurosci. 2016 Aug 31;36(35):9041-56. doi: 10.1523/JNEUROSCI.1023-16.2016. J Neurosci. 2016. PMID: 27581448 Free PMC article.

5

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.

Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Yang T, et al. J Neurosci. 2017 Jan 4;37(1):152-163. doi: 10.1523/JNEUROSCI.1698-16.2016. J Neurosci. 2017. PMID: 28053038 Free PMC article.

6

A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.

Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. Xia W, et al. Among authors: yang t. Arch Neurol. 2009 Feb;66(2):190-9. doi: 10.1001/archneurol.2008.565. Arch Neurol. 2009. PMID: 19204155 Free PMC article.

7

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.

Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Jin M, et al. Among authors: yang t. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5819-24. doi: 10.1073/pnas.1017033108. Epub 2011 Mar 18. Proc Natl Acad Sci U S A. 2011. PMID: 21421841 Free PMC article.

8

Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study.

Townsend MK, Okereke OI, Xia W, Yang T, Selkoe DJ, Grodstein F. Townsend MK, et al. Among authors: yang t. Alzheimer Dis Assoc Disord. 2012 Jan-Mar;26(1):50-4. doi: 10.1097/WAD.0b013e31821764ce. Alzheimer Dis Assoc Disord. 2012. PMID: 21502851 Free PMC article.

9

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid.

Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ. Yang T, et al. Ann Neurol. 2019 Aug;86(2):215-224. doi: 10.1002/ana.25513. Epub 2019 Jun 22. Ann Neurol. 2019. PMID: 31168802 Free PMC article. Clinical Trial.

10

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ. Li S, et al. Among authors: yang t. Neuron. 2013 Mar 6;77(5):929-41. doi: 10.1016/j.neuron.2012.12.040. Neuron. 2013. PMID: 23473322 Free PMC article.

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