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Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Hampton SE, Baragaña B, Schipani A, Bosch-Navarrete C, Musso-Buendía JA, Recio E, Kaiser M, Whittingham JL, Roberts SM, Shevtsov M, Brannigan JA, Kahnberg P, Brun R, Wilson KS, González-Pacanowska D, Johansson NG, Gilbert IH. Hampton SE, et al. ChemMedChem. 2011 Oct 4;6(10):1816-31. doi: 10.1002/cmdc.201100255. ChemMedChem. 2011. PMID: 22049550
New crystal forms of Trypanosoma cruzi dUTPase.
Harkiolaki M, Brzozowski AM, Gonzalez-Pacanowska D, Hidalgo-Zarco F, Wilson KS. Harkiolaki M, et al. Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):915-7. doi: 10.1107/s0907444901004905. Epub 2001 May 25. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11375528
Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.
Zuccotto F, Zvelebil M, Brun R, Chowdhury SF, Di Lucrezia R, Leal I, Maes L, Ruiz-Perez LM, Gonzalez Pacanowska D, Gilbert IH. Zuccotto F, et al. Eur J Med Chem. 2001 May;36(5):395-405. doi: 10.1016/s0223-5234(01)01235-1. Eur J Med Chem. 2001. PMID: 11451529
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.
Whittingham JL, Leal I, Nguyen C, Kasinathan G, Bell E, Jones AF, Berry C, Benito A, Turkenburg JP, Dodson EJ, Ruiz Perez LM, Wilkinson AJ, Johansson NG, Brun R, Gilbert IH, Gonzalez Pacanowska D, Wilson KS. Whittingham JL, et al. Structure. 2005 Feb;13(2):329-38. doi: 10.1016/j.str.2004.11.015. Structure. 2005. PMID: 15698576 Free article.
151 results