Chin AC - Search Results

1

Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types.

Yung LY, Lam WS, Ho MK, Hu Y, Ip FC, Pang H, Chin AC, Harley CB, Ip NY, Wong YH. Yung LY, et al. Among authors: chin ac. Planta Med. 2012 Jan;78(2):115-21. doi: 10.1055/s-0031-1280346. Epub 2011 Nov 14. Planta Med. 2012. PMID: 22083896

2

Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.

Ip FC, Ng YP, An HJ, Dai Y, Pang HH, Hu YQ, Chin AC, Harley CB, Wong YH, Ip NY. Ip FC, et al. Among authors: chin ac. Neurosignals. 2014;22(1):52-63. doi: 10.1159/000365290. Epub 2014 Jul 31. Neurosignals. 2014. PMID: 25095809 Free article.

3

In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator.

Zhu J, Lee S, Ho MK, Hu Y, Pang H, Ip FC, Chin AC, Harley CB, Ip NY, Wong YH. Zhu J, et al. Among authors: chin ac. Drug Metab Pharmacokinet. 2010;25(5):477-86. doi: 10.2133/dmpk.dmpk-10-rg-037. Epub 2010 Sep 22. Drug Metab Pharmacokinet. 2010. PMID: 20877137 Free article.

4

Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition.

Herbert BS, Gellert GC, Hochreiter A, Pongracz K, Wright WE, Zielinska D, Chin AC, Harley CB, Shay JW, Gryaznov SM. Herbert BS, et al. Among authors: chin ac. Oncogene. 2005 Aug 4;24(33):5262-8. doi: 10.1038/sj.onc.1208760. Oncogene. 2005. PMID: 15940257

5

Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.

Fauce SR, Jamieson BD, Chin AC, Mitsuyasu RT, Parish ST, Ng HL, Kitchen CM, Yang OO, Harley CB, Effros RB. Fauce SR, et al. Among authors: chin ac. J Immunol. 2008 Nov 15;181(10):7400-6. doi: 10.4049/jimmunol.181.10.7400. J Immunol. 2008. PMID: 18981163 Free PMC article.

6

A novel telomerase template antagonist (GRN163) as a potential anticancer agent.

Asai A, Oshima Y, Yamamoto Y, Uochi TA, Kusaka H, Akinaga S, Yamashita Y, Pongracz K, Pruzan R, Wunder E, Piatyszek M, Li S, Chin AC, Harley CB, Gryaznov S. Asai A, et al. Among authors: chin ac. Cancer Res. 2003 Jul 15;63(14):3931-9. Cancer Res. 2003. PMID: 12873987

7

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma.

Djojosubroto MW, Chin AC, Go N, Schaetzlein S, Manns MP, Gryaznov S, Harley CB, Rudolph KL. Djojosubroto MW, et al. Among authors: chin ac. Hepatology. 2005 Nov;42(5):1127-36. doi: 10.1002/hep.20822. Hepatology. 2005. PMID: 16114043

8

Oligonucleotide N3' --> P5' thio-phosphoramidate telomerase template antagonists as potential anticancer agents.

Gryaznov S, Asai A, Oshima Y, Yamamoto Y, Pongracz K, Pruzan R, Wunder E, Piatyszek M, Li S, Chin A, Harley C, Akinaga S, Yamashita Y. Gryaznov S, et al. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):577-81. doi: 10.1081/NCN-120021958. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565232

9

Telomerase inhibitors--oligonucleotide phosphoramidates as potential therapeutic agents.

Gryaznov S, Pongracz K, Matray T, Schultz R, Pruzan R, Aimi J, Chin A, Harley C, Shea-Herbert B, Shay J, Oshima Y, Asai A, Yamashita Y. Gryaznov S, et al. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):401-10. doi: 10.1081/NCN-100002314. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11563055

10

IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence.

Xing C, Shi L, Zhu L, Aguirre T, Qi J, Chen Y, Liu Y, Chin AC, Zhu H, Fiedler D, Chen AF, Fu C. Xing C, et al. Among authors: chin ac. Diabetes. 2025 Jan 10:db240706. doi: 10.2337/db24-0706. Online ahead of print. Diabetes. 2025. PMID: 39792359

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