Geraghty RJ - Search Results

1

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.

Chen YL, Tang J, Kesler MJ, Sham YY, Vince R, Geraghty RJ, Wang Z. Chen YL, et al. Among authors: geraghty rj. Bioorg Med Chem. 2012 Jan 1;20(1):467-79. doi: 10.1016/j.bmc.2011.10.058. Epub 2011 Oct 24. Bioorg Med Chem. 2012. PMID: 22100256

2

C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus.

Chen YL, Zacharias J, Vince R, Geraghty RJ, Wang Z. Chen YL, et al. Among authors: geraghty rj. Bioorg Med Chem. 2012 Aug 1;20(15):4790-800. doi: 10.1016/j.bmc.2012.05.066. Epub 2012 Jun 7. Bioorg Med Chem. 2012. PMID: 22748708

3

Mutations in the amino terminus of herpes simplex virus type 1 gL can reduce cell-cell fusion without affecting gH/gL trafficking.

Zhou W, Chen F, Klyachkin Y, Sham YY, Geraghty RJ. Zhou W, et al. Among authors: geraghty rj. J Virol. 2014 Jan;88(1):739-44. doi: 10.1128/JVI.02383-13. Epub 2013 Oct 23. J Virol. 2014. PMID: 24155377 Free PMC article.

4

Hydroxamic acids block replication of hepatitis C virus.

Ai T, Xu Y, Qiu L, Geraghty RJ, Chen L. Ai T, et al. Among authors: geraghty rj. J Med Chem. 2015 Jan 22;58(2):785-800. doi: 10.1021/jm501330g. Epub 2014 Dec 19. J Med Chem. 2015. PMID: 25490700

5

5'-Silylated 3'-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus.

Vernekar SK, Qiu L, Zhang J, Kankanala J, Li H, Geraghty RJ, Wang Z. Vernekar SK, et al. Among authors: geraghty rj. J Med Chem. 2015 May 14;58(9):4016-28. doi: 10.1021/acs.jmedchem.5b00327. Epub 2015 May 4. J Med Chem. 2015. PMID: 25909386 Free PMC article.

6

Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.

Ai T, Qiu L, Xie J, Geraghty RJ, Chen L. Ai T, et al. Among authors: geraghty rj. Bioorg Med Chem. 2016 Feb 15;24(4):686-92. doi: 10.1016/j.bmc.2015.12.035. Epub 2015 Dec 23. Bioorg Med Chem. 2016. PMID: 26753813

7

Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage.

Wang Y, Mao L, Kankanala J, Wang Z, Geraghty RJ. Wang Y, et al. Among authors: geraghty rj. J Virol. 2017 Jan 18;91(3):e02152-16. doi: 10.1128/JVI.02152-16. Print 2017 Feb 1. J Virol. 2017. PMID: 27881652 Free PMC article.

8

Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication.

Wang Y, Tang J, Wang Z, Geraghty RJ. Wang Y, et al. Among authors: geraghty rj. Antiviral Res. 2018 Apr;152:10-17. doi: 10.1016/j.antiviral.2018.01.015. Epub 2018 Feb 6. Antiviral Res. 2018. PMID: 29425830

9

Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.

Kankanala J, Wang Y, Geraghty RJ, Wang Z. Kankanala J, et al. Among authors: geraghty rj. ChemMedChem. 2018 Aug 20;13(16):1658-1663. doi: 10.1002/cmdc.201800283. Epub 2018 Jul 20. ChemMedChem. 2018. PMID: 29968426

10

Structure activity relationship, 6-modified purine riboside analogues to activate hSTING, stimulator of interferon genes.

Bonnac LF, Dreis CD, Geraghty RJ. Bonnac LF, et al. Among authors: geraghty rj. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126819. doi: 10.1016/j.bmcl.2019.126819. Epub 2019 Nov 12. Bioorg Med Chem Lett. 2020. PMID: 31780305

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