Ijzerman AP - Search Results

1

Which compound to select in lead optimization? Prospectively validated proteochemometric models guide preclinical development.

van Westen GJ, Wegner JK, Geluykens P, Kwanten L, Vereycken I, Peeters A, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. Among authors: ijzerman ap. PLoS One. 2011;6(11):e27518. doi: 10.1371/journal.pone.0027518. Epub 2011 Nov 23. PLoS One. 2011. PMID: 22132107 Free PMC article.

2

A model for the antagonist binding site on the adenosine A1 receptor, based on steric, electrostatic, and hydrophobic properties.

van Galen PJ, van Vlijmen HW, IJzerman AP, Soudijn W. van Galen PJ, et al. Among authors: ijzerman ap. J Med Chem. 1990 Jun;33(6):1708-13. doi: 10.1021/jm00168a027. J Med Chem. 1990. PMID: 2342066

3

Molecular modeling of a putative antagonist binding site on helix III of the beta-adrenoceptor.

van Vlijmen HW, IJzerman AP. van Vlijmen HW, et al. Among authors: ijzerman ap. J Comput Aided Mol Des. 1989 Jun;3(2):165-74. doi: 10.1007/BF01557726. J Comput Aided Mol Des. 1989. PMID: 2570825

4

A molecular graphics study exploring a putative ligand binding site of the beta-adrenoceptor.

IJzerman AP, van Vlijmen HW. IJzerman AP, et al. J Comput Aided Mol Des. 1988 Apr;2(1):43-53. doi: 10.1007/BF01532052. J Comput Aided Mol Des. 1988. PMID: 2848931

5

Substructure mining of GPCR ligands reveals activity-class specific functional groups in an unbiased manner.

van der Horst E, Okuno Y, Bender A, IJzerman AP. van der Horst E, et al. Among authors: ijzerman ap. J Chem Inf Model. 2009 Feb;49(2):348-60. doi: 10.1021/ci8003896. J Chem Inf Model. 2009. PMID: 19434836

6

Mining protein dynamics from sets of crystal structures using "consensus structures".

van Westen GJ, Wegner JK, Bender A, Ijzerman AP, van Vlijmen HW. van Westen GJ, et al. Among authors: ijzerman ap. Protein Sci. 2010 Apr;19(4):742-52. doi: 10.1002/pro.350. Protein Sci. 2010. PMID: 20120021 Free PMC article.

7

Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.

Doddareddy MR, Klaasse EC, Shagufta, Ijzerman AP, Bender A. Doddareddy MR, et al. Among authors: ijzerman ap. ChemMedChem. 2010 May 3;5(5):716-29. doi: 10.1002/cmdc.201000024. ChemMedChem. 2010. PMID: 20349498

8

A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization.

van der Horst E, Peironcely JE, Ijzerman AP, Beukers MW, Lane JR, van Vlijmen HW, Emmerich MT, Okuno Y, Bender A. van der Horst E, et al. Among authors: ijzerman ap. BMC Bioinformatics. 2010 Jun 10;11:316. doi: 10.1186/1471-2105-11-316. BMC Bioinformatics. 2010. PMID: 20537162 Free PMC article.

9

GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor.

Peeters MC, van Westen GJ, Guo D, Wisse LE, Müller CE, Beukers MW, Ijzerman AP. Peeters MC, et al. Among authors: ijzerman ap. FASEB J. 2011 Feb;25(2):632-43. doi: 10.1096/fj.10-164319. Epub 2010 Oct 28. FASEB J. 2011. PMID: 21030693

10

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation.

Peeters MC, van Westen GJ, Li Q, IJzerman AP. Peeters MC, et al. Among authors: ijzerman ap. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. doi: 10.1016/j.tips.2010.10.001. Trends Pharmacol Sci. 2011. PMID: 21075459 Review.

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