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Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis.
Kim JH, Gupta SC, Park B, Yadav VR, Aggarwal BB. Kim JH, et al. Among authors: aggarwal bb. Mol Nutr Food Res. 2012 Mar;56(3):454-65. doi: 10.1002/mnfr.201100270. Epub 2011 Dec 7. Mol Nutr Food Res. 2012. PMID: 22147524 Free PMC article.
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
Sung B, Park B, Yadav VR, Aggarwal BB. Sung B, et al. Among authors: aggarwal bb. J Biol Chem. 2010 Apr 9;285(15):11498-507. doi: 10.1074/jbc.M109.090209. Epub 2010 Feb 12. J Biol Chem. 2010. Retraction in: J Biol Chem. 2016 Aug 5;291(32):16920. doi: 10.1074/jbc.A109.090209 PMID: 20154087 Free PMC article. Retracted.
Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.
Yadav VR, Prasad S, Kannappan R, Ravindran J, Chaturvedi MM, Vaahtera L, Parkkinen J, Aggarwal BB. Yadav VR, et al. Among authors: aggarwal bb. Biochem Pharmacol. 2010 Oct 1;80(7):1021-32. doi: 10.1016/j.bcp.2010.06.022. Epub 2010 Jun 23. Biochem Pharmacol. 2010. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:142. doi: 10.1016/j.bcp.2015.11.007 PMID: 20599780 Free PMC article. Retracted.
Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.
Kannappan R, Ravindran J, Prasad S, Sung B, Yadav VR, Reuter S, Chaturvedi MM, Aggarwal BB. Kannappan R, et al. Among authors: aggarwal bb. Mol Cancer Ther. 2010 Aug;9(8):2196-207. doi: 10.1158/1535-7163.MCT-10-0277. Epub 2010 Aug 3. Mol Cancer Ther. 2010. Retraction in: Mol Cancer Ther. 2018 Sep;17(9):2072. doi: 10.1158/1535-7163.MCT-18-0869 PMID: 20682650 Retracted.
Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.
Reuter S, Prasad S, Phromnoi K, Kannappan R, Yadav VR, Aggarwal BB. Reuter S, et al. Among authors: aggarwal bb. Mol Cancer Res. 2010 Oct;8(10):1425-36. doi: 10.1158/1541-7786.MCR-10-0141. Epub 2010 Sep 8. Mol Cancer Res. 2010. Retraction in: Mol Cancer Res. 2018 Sep;16(9):1443. doi: 10.1158/1541-7786.MCR-18-0818 PMID: 20826545 Free PMC article. Retracted.
Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB. Gupta SC, et al. Among authors: aggarwal bb. J Biol Chem. 2010 Nov 12;285(46):35406-17. doi: 10.1074/jbc.M110.161984. Epub 2010 Sep 9. J Biol Chem. 2010. PMID: 20829362 Free PMC article.
{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.
Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Yadav VR, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. Kunnumakkara AB, et al. Among authors: aggarwal bb. Cancer Res. 2010 Nov 1;70(21):8695-705. doi: 10.1158/0008-5472.CAN-10-2318. Epub 2010 Sep 23. Cancer Res. 2010. PMID: 20864511 Free PMC article.
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB. Phromnoi K, et al. Among authors: aggarwal bb. Mol Pharmacol. 2011 Feb;79(2):279-89. doi: 10.1124/mol.110.067512. Epub 2010 Oct 7. Mol Pharmacol. 2011. Retraction in: Mol Pharmacol. 2016 Jul;90(1):64. doi: 10.1124/mol.115.067512retraction PMID: 20930110 Free PMC article. Retracted.
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.
Reuter S, Prasad S, Phromnoi K, Ravindran J, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Reuter S, et al. Among authors: aggarwal bb. Cancer Prev Res (Phila). 2010 Nov;3(11):1462-72. doi: 10.1158/1940-6207.CAPR-10-0037. Epub 2010 Oct 26. Cancer Prev Res (Phila). 2010. PMID: 20978115 Free PMC article.
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.
Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, Nair M, Aggarwal BB. Gupta SC, et al. Among authors: aggarwal bb. J Biol Chem. 2011 Jan 14;286(2):1134-46. doi: 10.1074/jbc.M110.191379. Epub 2010 Nov 15. J Biol Chem. 2011. Retraction in: J Biol Chem. 2016 Aug 5;291(32):16925. doi: 10.1074/jbc.A110.191379 PMID: 21078664 Free PMC article. Retracted.
658 results