Melnick M - Search Results

1

Potent inhibitors of LpxC for the treatment of Gram-negative infections.

Brown MF, Reilly U, Abramite JA, Arcari JT, Oliver R, Barham RA, Che Y, Chen JM, Collantes EM, Chung SW, Desbonnet C, Doty J, Doroski M, Engtrakul JJ, Harris TM, Huband M, Knafels JD, Leach KL, Liu S, Marfat A, Marra A, McElroy E, Melnick M, Menard CA, Montgomery JI, Mullins L, Noe MC, O'Donnell J, Penzien J, Plummer MS, Price LM, Shanmugasundaram V, Thoma C, Uccello DP, Warmus JS, Wishka DG. Brown MF, et al. Among authors: melnick m. J Med Chem. 2012 Jan 26;55(2):914-23. doi: 10.1021/jm2014748. Epub 2012 Jan 11. J Med Chem. 2012. PMID: 22175825

2

Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents.

Vara Prasad JV, Boyer FE, Chupak L, Dermyer M, Ding Q, Gavardinas K, Hagen SE, Huband MD, Jiao W, Kaneko T, Maiti SN, Melnick M, Romero K, Patterson M, Wu X. Vara Prasad JV, et al. Among authors: melnick m. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5392-7. doi: 10.1016/j.bmcl.2006.07.064. Epub 2006 Aug 9. Bioorg Med Chem Lett. 2006. PMID: 16901693

3

Structure-based design and synthesis of substituted 2-butanols as nonpeptidic inhibitors of HIV protease: secondary amide series.

Reich SH, Melnick M, Pino MJ, Fuhry MA, Trippe AJ, Appelt K, Davies JF 2nd, Wu BW, Musick L. Reich SH, et al. Among authors: melnick m. J Med Chem. 1996 Jul 5;39(14):2781-94. doi: 10.1021/jm960093o. J Med Chem. 1996. PMID: 8709109

4

Bis tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design.

Melnick M, Reich SH, Lewis KK, Mitchell LJ Jr, Nguyen D, Trippe AJ, Dawson H, Davies JF 2nd, Appelt K, Wu BW, Musick L, Gehlhaar DK, Webber S, Shetty B, Kosa M, Kahil D, Andrada D. Melnick M, et al. J Med Chem. 1996 Jul 5;39(14):2795-811. doi: 10.1021/jm960092w. J Med Chem. 1996. PMID: 8709110

5

The use of biochemical and biophysical tools for triage of high-throughput screening hits - A case study with Escherichia coli phosphopantetheine adenylyltransferase.

Miller JR, Thanabal V, Melnick MM, Lall M, Donovan C, Sarver RW, Lee DY, Ohren J, Emerson D. Miller JR, et al. Among authors: melnick mm. Chem Biol Drug Des. 2010 May;75(5):444-54. doi: 10.1111/j.1747-0285.2010.00957.x. Chem Biol Drug Des. 2010. PMID: 20486930

6

Characterization of substrate binding and catalysis in the potential antibacterial target N-acetylglucosamine-1-phosphate uridyltransferase (GlmU).

Mochalkin I, Lightle S, Zhu Y, Ohren JF, Spessard C, Chirgadze NY, Banotai C, Melnick M, McDowell L. Mochalkin I, et al. Among authors: melnick m. Protein Sci. 2007 Dec;16(12):2657-66. doi: 10.1110/ps.073135107. Protein Sci. 2007. PMID: 18029420 Free PMC article.

7

Protein structure-based design of potent orally bioavailable, nonpeptide inhibitors of human immunodeficiency virus protease.

Reich SH, Melnick M, Davies JF 2nd, Appelt K, Lewis KK, Fuhry MA, Pino M, Trippe AJ, Nguyen D, Dawson H, et al. Reich SH, et al. Among authors: melnick m. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3298-302. doi: 10.1073/pnas.92.8.3298. Proc Natl Acad Sci U S A. 1995. PMID: 7724556 Free PMC article.

8

Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site.

Mochalkin I, Lightle S, Narasimhan L, Bornemeier D, Melnick M, Vanderroest S, McDowell L. Mochalkin I, et al. Among authors: melnick m. Protein Sci. 2008 Mar;17(3):577-82. doi: 10.1110/ps.073271408. Epub 2008 Jan 24. Protein Sci. 2008. PMID: 18218712 Free PMC article.

9

The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.

Bilder P, Lightle S, Bainbridge G, Ohren J, Finzel B, Sun F, Holley S, Al-Kassim L, Spessard C, Melnick M, Newcomer M, Waldrop GL. Bilder P, et al. Among authors: melnick m. Biochemistry. 2006 Feb 14;45(6):1712-22. doi: 10.1021/bi0520479. Biochemistry. 2006. PMID: 16460018

10

Limited restoration of contrast sensitivity with training after V1 damage in humans.

Yang 杨菁艺 J, Saionz EL, Cavanaugh MR, Fahrenthold BK, Melnick MD, Tadin D, Briggs F, Carrasco M, Huxlin KR. Yang 杨菁艺 J, et al. Among authors: melnick md. eNeuro. 2024 Feb 23;11(3):ENEURO.0020-24.2024. doi: 10.1523/ENEURO.0020-24.2024. Online ahead of print. eNeuro. 2024. PMID: 38395611 Free PMC article.

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