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A chemical chaperone improves muscle function in mice with a RyR1 mutation.
Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. Lee CS, et al. Among authors: dagnino acosta a. Nat Commun. 2017 Mar 24;8:14659. doi: 10.1038/ncomms14659. Nat Commun. 2017. PMID: 28337975 Free PMC article.
Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.
Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. Lee CS, et al. J Biol Chem. 2014 Sep 12;289(37):25556-70. doi: 10.1074/jbc.M114.586289. Epub 2014 Jul 22. J Biol Chem. 2014. PMID: 25053409 Free PMC article.
Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.
Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL. Lee CS, et al. Skelet Muscle. 2015 Jan 29;5:4. doi: 10.1186/s13395-014-0027-1. eCollection 2015. Skelet Muscle. 2015. PMID: 25717360 Free PMC article.
Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism.
Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. Georgiou DK, et al. Among authors: dagnino acosta a. J Biol Chem. 2015 Sep 25;290(39):23751-65. doi: 10.1074/jbc.M115.643544. Epub 2015 Aug 5. J Biol Chem. 2015. PMID: 26245899 Free PMC article.
17 results